Li Yanyun, Li Changying, Fan Junzi, Liu Yutong, Xu Yincong, Pang Guowei
School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China.
School of Ophthalmology and optometry, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China.
Cancer Manag Res. 2025 Jan 11;17:23-34. doi: 10.2147/CMAR.S503071. eCollection 2025.
Cancer immunotherapy is an advanced therapeutic approach that harnesses the body's immune system to target and eliminate tumor cells. Traditional Chinese medicine (TCM), with a history rooted in centuries of clinical practice, plays a crucial role in enhancing immune responses, alleviating cancer-related symptoms, and reducing the risks of infections and complications in cancer patients.
This review systematically examines the current literature on TCM-based formulations in cancer immunotherapy. It explores the mechanisms by which TCM augments immune responses, particularly focusing on how these formulations influence both innate and adaptive immunity. Various TCM herbs and compounds, their active ingredients, and their application in cancer prevention and treatment were analyzed through an integrated review of preclinical studies, clinical trials, and molecular mechanistic investigations.
TCM formulations contribute to cancer therapy by modulating the body's internal environment to improve immune defense. They enhance the immune system's ability to detect and destroy cancer cells, promote apoptosis in tumor cells, inhibit tumor growth and metastasis, and augment the effectiveness of conventional cancer treatments. The review highlights specific TCM herbs and formulations that have demonstrated significant anti-cancer properties, including their ability to strengthen immune responses and provide synergistic effects with existing cancer therapies.
TCM-derived formulations represent a promising addition to cancer immunotherapy. The mechanisms through which these formulations enhance anti-tumor immunity are multifaceted, involving modulation of immune cell activity, apoptosis induction, and suppression of tumor progression. As cancer immunotherapy evolves, the integration of TCM into conventional treatment regimens may offer enhanced therapeutic efficacy, reduced side effects, and improved overall outcomes for cancer patients. Further clinical research is needed to fully elucidate the therapeutic potential and safety of TCM-based immunotherapeutic strategies in cancer care.
癌症免疫疗法是一种先进的治疗方法，它利用人体免疫系统来靶向和消除肿瘤细胞。有着数百年临床实践历史的传统中医，在增强免疫反应、缓解癌症相关症状以及降低癌症患者感染和并发症风险方面发挥着关键作用。
本综述系统地研究了当前关于基于传统中医配方的癌症免疫疗法的文献。它探讨了传统中医增强免疫反应的机制，尤其关注这些配方如何影响先天免疫和适应性免疫。通过对临床前研究、临床试验和分子机制研究的综合综述，分析了各种传统中药草药和化合物、它们的活性成分以及它们在癌症预防和治疗中的应用。
传统中医配方通过调节人体内部环境来改善免疫防御，从而有助于癌症治疗。它们增强免疫系统检测和破坏癌细胞的能力，促进肿瘤细胞凋亡，抑制肿瘤生长和转移，并提高传统癌症治疗的效果。该综述强调了已显示出显著抗癌特性的特定传统中药草药和配方，包括它们增强免疫反应的能力以及与现有癌症疗法产生协同作用的能力。
源自传统中医的配方是癌症免疫疗法中一个有前景的补充。这些配方增强抗肿瘤免疫力的机制是多方面的，涉及免疫细胞活性的调节、凋亡诱导和肿瘤进展的抑制。随着癌症免疫疗法的发展，将传统中医纳入传统治疗方案可能会为癌症患者提供更高的治疗效果、更低的副作用和更好的总体预后。需要进一步的临床研究来充分阐明基于传统中医的免疫治疗策略在癌症护理中的治疗潜力和安全性。
