• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

硫化氢的产生并不影响. 的抗生素耐药性。

Hydrogen sulfide production does not affect antibiotic resistance in .

机构信息

Department of Science, University Roma Tre, Rome, Italy.

Department of Biotechnology, University of Verona, Verona, Italy.

出版信息

Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0007524. doi: 10.1128/aac.00075-24. Epub 2024 Mar 6.

DOI:10.1128/aac.00075-24
PMID:38445869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10989007/
Abstract

Hydrogen sulfide (HS) has been proposed to protect bacteria from antibiotics, pointing to HS-producing enzymes as possible targets for the development of antibiotic adjuvants. Here, MIC assays performed with mutants producing altered HS levels demonstrate that HS does not affect antibiotic resistance in this bacterium. Moreover, correlation analyses in a large collection of cystic fibrosis isolates argue against the protective role of HS from antibiotic activity during chronic lung infection.

摘要

硫化氢 (HS) 被认为可以保护细菌免受抗生素的影响，这表明产生 HS 的酶可能是开发抗生素佐剂的潜在靶点。在这里，通过产生改变 HS 水平的突变体进行 MIC 测定表明，HS 不会影响该细菌的抗生素耐药性。此外，在大量囊性纤维化分离株中的相关性分析表明，在慢性肺部感染期间，HS 对抗生素活性没有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bb0/10989007/d764d8b744f4/aac.00075-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bb0/10989007/857bd8a00f77/aac.00075-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bb0/10989007/d764d8b744f4/aac.00075-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bb0/10989007/857bd8a00f77/aac.00075-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bb0/10989007/d764d8b744f4/aac.00075-24.f002.jpg

相似文献

1
Hydrogen sulfide production does not affect antibiotic resistance in .硫化氢的产生并不影响. 的抗生素耐药性。
Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0007524. doi: 10.1128/aac.00075-24. Epub 2024 Mar 6.
2
Pseudomonas aeruginosa chromosomal beta-lactamase in patients with cystic fibrosis and chronic lung infection. Mechanism of antibiotic resistance and target of the humoral immune response.囊性纤维化和慢性肺部感染患者中的铜绿假单胞菌染色体β-内酰胺酶。抗生素耐药机制及体液免疫反应靶点。
APMIS Suppl. 2003(116):1-47.
3
Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin against Cystic Fibrosis Pseudomonas aeruginosa.格拉替雷醋酸酯与妥布霉素联合应用对囊性纤维化铜绿假单胞菌的协同作用。
Microbiol Spectr. 2022 Aug 31;10(4):e0081322. doi: 10.1128/spectrum.00813-22. Epub 2022 Jun 21.
4
Antibiotic Resistance in Pseudomonas.铜绿假单胞菌的抗生素耐药性。
Adv Exp Med Biol. 2022;1386:117-143. doi: 10.1007/978-3-031-08491-1_5.
5
The Effects of Antibiotic Combination Treatments on Pseudomonas aeruginosa Tolerance Evolution and Coexistence with Stenotrophomonas maltophilia.抗生素联合治疗对铜绿假单胞菌耐受进化和与嗜麦芽寡养单胞菌共存的影响。
Microbiol Spectr. 2022 Dec 21;10(6):e0184222. doi: 10.1128/spectrum.01842-22. Epub 2022 Dec 1.
6
Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients.铜绿假单胞菌抗生素耐药基因在囊性纤维化患者感染过程中的表达差异很大。
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01789-18. Print 2018 Nov.
7
Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Cefiderocol, and Novel Darobactin Analogs against Multidrug-Resistant Pseudomonas aeruginosa Isolates from Pediatric and Adolescent Cystic Fibrosis Patients.头孢他啶-阿维巴坦、头孢洛扎-他唑巴坦、头孢地尔、新型达罗巴坦类似物对儿科和青少年囊性纤维化患者多药耐药铜绿假单胞菌分离株的抗菌活性。
Microbiol Spectr. 2023 Feb 14;11(1):e0443722. doi: 10.1128/spectrum.04437-22. Epub 2023 Jan 24.
8
Time-Kill Evaluation of Antibiotic Combinations Containing Ceftazidime-Avibactam against Extensively Drug-Resistant Pseudomonas aeruginosa and Their Potential Role against Ceftazidime-Avibactam-Resistant Isolates.含头孢他啶-阿维巴坦的抗生素组合对广泛耐药铜绿假单胞菌的时间杀菌评估及其对头孢他啶-阿维巴坦耐药分离株的潜在作用。
Microbiol Spectr. 2021 Sep 3;9(1):e0058521. doi: 10.1128/Spectrum.00585-21. Epub 2021 Jul 28.
9
Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis.囊性纤维化患者铜绿假单胞菌慢性感染急性加重期的联合抗菌药物敏感性试验
Cochrane Database Syst Rev. 2017 Jun 19;6(6):CD006961. doi: 10.1002/14651858.CD006961.pub4.
10
Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis.囊性纤维化患者铜绿假单胞菌慢性感染急性加重期的联合抗菌药敏试验
Cochrane Database Syst Rev. 2020 May 15;5(5):CD006961. doi: 10.1002/14651858.CD006961.pub5.

引用本文的文献

1
Effect of watering before slaughter and the evisceration method on the quality characteristics of fattened goose liver.屠宰前浇水及去内脏方法对育肥鹅肝品质特性的影响
Poult Sci. 2024 Dec;103(12):104454. doi: 10.1016/j.psj.2024.104454. Epub 2024 Oct 29.
2
Effect of HS and cysteine homeostasis disturbance on ciprofloxacin sensitivity of Escherichia coli in cystine-free and cystine-fed minimal medium.HS 和半胱氨酸稳态紊乱对胱氨酸缺乏和胱氨酸喂养最小培养基中大肠杆菌对环丙沙星敏感性的影响。
Arch Microbiol. 2024 Nov 4;206(12):456. doi: 10.1007/s00203-024-04185-z.
3
Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa.

本文引用的文献

1
Naphthyl-Substituted Indole and Pyrrole Carboxylic Acids as Effective Antibiotic Potentiators-Inhibitors of Bacterial Cystathionine γ-Lyase.萘基取代吲哚和吡咯羧酸作为有效的抗生素增效剂-细菌胱硫醚γ-裂解酶抑制剂。
Int J Mol Sci. 2023 Nov 15;24(22):16331. doi: 10.3390/ijms242216331.
2
Cystathionine γ-lyase: The Achilles heel of bacterial defense systems.胱硫醚γ-裂合酶：细菌防御系统的致命弱点。
Int J Antimicrob Agents. 2023 Jul;62(1):106845. doi: 10.1016/j.ijantimicag.2023.106845. Epub 2023 May 13.
3
Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019.
铜绿假单胞菌胱硫醚γ-裂合酶的催化特异性和晶体结构
Sci Rep. 2024 Apr 23;14(1):9364. doi: 10.1038/s41598-024-57625-7.
4
Cyanide Insensitive Oxidase Confers Hydrogen Sulfide and Nitric Oxide Tolerance to Aerobic Respiration.氰化物不敏感氧化酶赋予需氧呼吸对硫化氢和一氧化氮的耐受性。
Antioxidants (Basel). 2024 Mar 21;13(3):383. doi: 10.3390/antiox13030383.
2019 年与 33 种细菌病原体相关的全球死亡率：2019 年全球疾病负担研究的系统分析。
Lancet. 2022 Dec 17;400(10369):2221-2248. doi: 10.1016/S0140-6736(22)02185-7. Epub 2022 Nov 21.
4
Molecular mechanisms of antibiotic resistance revisited.抗生素耐药性的分子机制再探讨。
Nat Rev Microbiol. 2023 May;21(5):280-295. doi: 10.1038/s41579-022-00820-y. Epub 2022 Nov 21.
5
Enhancement of the Bactericidal Effect of Antibiotics by Inhibition of Enzymes Involved in Production of Hydrogen Sulfide in Bacteria.通过抑制细菌中参与硫化氢产生的酶来增强抗生素的杀菌效果。
Mol Biol. 2022;56(5):638-648. doi: 10.1134/S0026893322050120. Epub 2022 Oct 5.
6
Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence.产芽短杆菌中硫化氢生物合成的遗传决定因素对细菌适应性、抗生素敏感性和毒力是必需的。
mBio. 2022 Oct 26;13(5):e0193622. doi: 10.1128/mbio.01936-22. Epub 2022 Sep 8.
7
PqsE Expands and Differentially Modulates the RhlR Quorum Sensing Regulon in Pseudomonas aeruginosa.PqsE 扩展并差异化调节铜绿假单胞菌中的 RhlR 群体感应调控基因。
Microbiol Spectr. 2022 Jun 29;10(3):e0096122. doi: 10.1128/spectrum.00961-22. Epub 2022 May 23.
8
Activity of Antivirulence Drugs Targeting the or Quorum Sensing Against Cystic Fibrosis Isolates.靶向或群体感应的抗毒力药物对囊性纤维化分离株的活性。
Front Microbiol. 2022 Apr 25;13:845231. doi: 10.3389/fmicb.2022.845231. eCollection 2022.
9
HS Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility.透明质酸作为一个汇聚点来调节中枢代谢、生物能量学和药物敏感性。
Antioxidants (Basel). 2021 Aug 13;10(8):1285. doi: 10.3390/antiox10081285.
10
Inhibitors of bacterial HS biogenesis targeting antibiotic resistance and tolerance.靶向抗生素耐药性和耐受性的细菌 HS 生物合成抑制剂。
Science. 2021 Jun 11;372(6547):1169-1175. doi: 10.1126/science.abd8377.