低热量饮食联合或不联合鱼油补充剂对肥胖中年女性进行减肥治疗可重建铁和 ω-3 脂肪酸的体内平衡：一项随机对照试验的事后分析。

Weight loss induced by a hypocaloric diet with or without fish oil supplementation re-established iron and omega-3 fatty acid homeostasis in middle-aged women with obesity: A post-hoc analysis of a randomized controlled trial.

机构信息

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan.

Department of Nutrition, Faculty of Sports and Health Sciences, Universitas Negeri Surabaya, Surabaya 60213, Indonesia.

出版信息

Maturitas. 2024 Jun;184:107948. doi: 10.1016/j.maturitas.2024.107948. Epub 2024 Feb 24.

DOI:10.1016/j.maturitas.2024.107948

PMID:38447232

Abstract

OBJECTIVE

Middle-aged women with obesity are at increased risk of iron overload and iron disorder is known to disrupt n-3 polyunsaturated fatty acid homeostasis. We evaluated relationships between pretreatment hemoglobin and n-3 polyunsaturated fatty acid levels, and tested whether pretreatment hemoglobin contributed to inter-individual variability in weight loss with special focus on changes in body weight, iron and n-3 polyunsaturated fatty acid profiles.

STUDY DESIGN

117 middle and older aged women with obesity and more than two metabolic abnormalities were randomized to a 12-week hypocaloric diet without or with fish oil supplementation. Blood iron biomarker and erythrocyte membrane phospholipid profiles were evaluated.

MAIN OUTCOME

The absolute change from baseline to week 12 in serum iron and erythrocyte n-3 polyunsaturated fatty acid levels according to pretreatment hemoglobin tertiles and fish oil supplementation.

RESULTS

A Pearson correlation analysis showed that pretreatment hemoglobin levels were negatively correlated with linoleic acid (r = -0.231), α-linoleic acid (r = -0.279), and n-3 polyunsaturated fatty acid (r = -0.217) (all p < 0.05). Dietary weight loss markedly enhanced erythrocyte membrane lipids of linoleic acid, α-linoleic acid, and n-6 and n-3 polyunsaturated fatty acid only in those women with the highest pretreatment hemoglobin levels (tertile 3) (all p < 0.05). Fish oil supplementation increased bioavailable iron in women with moderate pretreatment hemoglobin levels (tertile 2) (p < 0.05) and, to a lesser extent, prevented a reduction in circulating iron in those with the lowest hemoglobin levels (tertile 1).

CONCLUSION

Dietary weight loss is an effective treatment program to manage obesity-related iron and n-3 polyunsaturated fatty acid disorders, particularly for middle-aged women with obesity and iron overload.

摘要

目的

肥胖的中年女性患铁过载的风险增加，而铁代谢紊乱已知会破坏 n-3 多不饱和脂肪酸的动态平衡。我们评估了预处理血红蛋白与 n-3 多不饱和脂肪酸水平之间的关系，并测试了预处理血红蛋白是否导致个体间减肥效果的差异，特别关注体重、铁和 n-3 多不饱和脂肪酸谱的变化。

研究设计

117 名患有肥胖症和两种以上代谢异常的中老年女性被随机分为低热量饮食 12 周组，不补充鱼油或补充鱼油。评估血液铁生物标志物和红细胞膜磷脂谱。

主要结果

根据预处理血红蛋白三分位和鱼油补充，从基线到第 12 周血清铁和红细胞 n-3 多不饱和脂肪酸水平的绝对变化。

结果

Pearson 相关分析显示，预处理血红蛋白水平与亚油酸（r=-0.231）、α-亚麻酸（r=-0.279）和 n-3 多不饱和脂肪酸（r=-0.217）呈负相关（均 p<0.05）。饮食减肥仅在预处理血红蛋白水平最高的女性（三分位 3）中显著增强了红细胞膜中亚油酸、α-亚麻酸和 n-6 和 n-3 多不饱和脂肪酸的含量（均 p<0.05）。鱼油补充增加了中等预处理血红蛋白水平（三分位 2）的生物可利用铁（p<0.05），并在一定程度上防止了血红蛋白水平最低的女性（三分位 1）循环铁的减少。