雌激素相关受体 α：与年龄相关性黄斑变性相关的潜在调节剂。
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration.
机构信息
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.
出版信息
Curr Opin Pharmacol. 2024 Apr;75:102439. doi: 10.1016/j.coph.2024.102439. Epub 2024 Mar 5.
To develop effective therapies for complex blinding diseases such as age-related macular degeneration (AMD), identification of mechanisms involved in its initiation and progression is needed. The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor that regulates several AMD-associated pathogenic pathways. However, it has not been investigated in detail in the ocular posterior pole during aging or in AMD. This review delves into the literature highlighting the significance of ESRRA as a molecular target that may be important in the pathobiology of AMD, and discusses data available supporting the targeting of this receptor signaling pathway as a therapeutic option for AMD.
为了开发针对年龄相关性黄斑变性（AMD）等复杂致盲性疾病的有效疗法，需要确定其起始和进展所涉及的机制。雌激素相关受体α（ESRRA）是一种孤儿核受体，可调节几种与 AMD 相关的致病途径。然而，在衰老或 AMD 过程中，其在眼部后极的作用尚未得到详细研究。本综述深入探讨了文献，强调了 ESRRA 作为 AMD 病理生物学中重要的分子靶标，同时讨论了支持靶向该受体信号通路作为 AMD 治疗选择的现有数据。
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