Chen X M, Wang X J, Xu S C, Zhang X L, Wang D S, Shan S G, Hu X W
Department of Pulmonary and Critical Care Medicine, Rare Diseases Center of Diagnosis and Management, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2024 Mar 12;47(3):232-236. doi: 10.3760/cma.j.cn112147-20231116-00315.
Rheumatoid arthritis (RA), a chronic autoimmune disorder, is characterized by erosive inflammation of bone and cartilage, leading to progressive joint destruction. Pulmonary involvement occurs in approximately 60% of RA patients, manifests most commonly as interstitial lung disease and, less commonly, as rheumatoid lung nodules. Here, we report a 50-year-old woman, non-smoker, with recurrent cough and sputum of 7 years' duration, accompanied by a chest CT showing multiple cavitary nodules in both lungs. She had been treated empirically at several medical centers and was finally diagnosed with rheumatoid lung nodules. Marked improvement in rheumatoid lung nodules was observed after treatment with tocilizumab in combination with glucocorticoids and leflunomide. The aim of this study was to improve clinicians' understanding of rheumatoid lung nodules by analyzing the clinical features, diagnosis, and treatment of this case, and reviewing the relevant medical literature.
类风湿关节炎（RA）是一种慢性自身免疫性疾病，其特征是骨和软骨的侵蚀性炎症，导致关节进行性破坏。约60%的RA患者会出现肺部受累，最常见的表现为间质性肺病，较少见的表现为类风湿肺结节。在此，我们报告一名50岁不吸烟女性，有7年反复咳嗽、咳痰病史，胸部CT显示双肺多发空洞性结节。她曾在多家医疗中心接受经验性治疗，最终被诊断为类风湿肺结节。使用托珠单抗联合糖皮质激素和来氟米特治疗后，类风湿肺结节有明显改善。本研究的目的是通过分析该病例的临床特征、诊断和治疗，并复习相关医学文献，提高临床医生对类风湿肺结节的认识。
