使用运动单位 MRI 检测肌萎缩侧索硬化症的全身肌束震颤。

Whole-body fasciculation detection in amyotrophic lateral sclerosis using motor unit MRI.

机构信息

Newcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle Upon Tyne, United Kingdom.

Newcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle Upon Tyne, United Kingdom; Newcastle Biomedical Research Centre (BRC), Newcastle University, Newcastle Upon Tyne, United Kingdom; Northern Medical Physics and Clinical Engineering, Freeman Hospital, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.

出版信息

Clin Neurophysiol. 2024 May;161:246-255. doi: 10.1016/j.clinph.2024.02.016. Epub 2024 Feb 18.

DOI:10.1016/j.clinph.2024.02.016

PMID:38448302

Abstract

OBJECTIVE

Compare fasciculation rates between amyotrophic lateral sclerosis (ALS) patients and healthy controls in body regions relevant for diagnosing ALS using motor unit MRI (MUMRI) at baseline and 6 months follow-up, and relate this to single-channel surface EMG (SEMG).

METHODS

Tongue, biceps brachii, paraspinals and lower legs were assessed with MUMRI and biceps brachii and soleus with SEMG in 10 healthy controls and 10 patients (9 typical ALS, 1 primary lateral sclerosis [PLS]).

RESULTS

MUMRI-detected fasciculation rates in typical ALS patients were higher compared to healthy controls for biceps brachii (2.40 ± 1.90 cmminvs. 0.04 ± 0.10 cmmin, p = 0.004), paraspinals (1.14 ± 1.61 cmminvs. 0.02 ± 0.02 cmmin, p = 0.016) and lower legs (1.42 ± 1.27 cmminvs. 0.13 ± 0.10 cmmin, p = 0.004), but not tongue (1.41 ± 1.94 cmminvs. 0.18 ± 0.18 cmmin, p = 0.556). The PLS patient showed no fasciculation. At baseline, 6/9 ALS patients had increased fasciculation rates compared to healthy controls in at least 2 body regions. At follow-up every patient had increased fasciculation rates in at least 2 body regions. The MUMRI-detected fasciculation rate correlated with SEMG-detected fasciculation rates (τ = 0.475, p = 0.006).

CONCLUSION

MUMRI can non-invasively image fasciculation in multiple body regions and appears sensitive to disease progression in individual patients.

SIGNIFICANCE

MUMRI has potential as diagnostic tool for ALS.

摘要

目的

使用运动单位 MRI（MUMRI）在基线和 6 个月随访时比较肌萎缩侧索硬化症（ALS）患者和健康对照者在与诊断 ALS 相关的身体区域中的肌束颤动率，并将其与单通道表面肌电图（SEMG）相关联。

方法

10 名健康对照者和 10 名患者（9 名典型 ALS，1 名原发性侧索硬化症[PLS]）接受了 MUMRI 评估舌、肱二头肌、椎旁肌和小腿，以及 SEMG 评估肱二头肌和比目鱼肌。

结果

与健康对照组相比，典型 ALS 患者的 MUMRI 检测到的肌束颤动率在肱二头肌（2.40±1.90 cmmin 与 0.04±0.10 cmmin，p=0.004）、椎旁肌（1.14±1.61 cmmin 与 0.02±0.02 cmmin，p=0.016）和小腿（1.42±1.27 cmmin 与 0.13±0.10 cmmin，p=0.004）中更高，但舌部（1.41±1.94 cmmin 与 0.18±0.18 cmmin，p=0.556）中没有。该 PLS 患者没有肌束颤动。在基线时，9 名 ALS 患者中有 6 名在至少 2 个身体区域中的肌束颤动率高于健康对照组。在随访时，每位患者至少在 2 个身体区域中增加了肌束颤动率。MUMRI 检测到的肌束颤动率与 SEMG 检测到的肌束颤动率相关（τ=0.475，p=0.006）。