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躯干出血:无法压迫?切勿轻言放弃。

Torso hemorrhage: noncompressible? never say never.

机构信息

Department of Trauma Surgery, War Trauma Medical Center, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China.

出版信息

Eur J Med Res. 2024 Mar 6;29(1):153. doi: 10.1186/s40001-024-01760-4.

DOI:10.1186/s40001-024-01760-4
PMID:38448977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10919054/
Abstract

Since limb bleeding has been well managed by extremity tourniquets, the management of exsanguinating torso hemorrhage (TH) has become a hot issue both in military and civilian medicine. Conventional hemostatic techniques are ineffective for managing traumatic bleeding of organs and vessels within the torso due to the anatomical features. The designation of noncompressible torso hemorrhage (NCTH) marks a significant step in investigating the injury mechanisms and developing effective methods for bleeding control. Special tourniquets such as abdominal aortic and junctional tourniquet and SAM junctional tourniquet designed for NCTH have been approved by FDA for clinical use. Combat ready clamp and junctional emergency treatment tool also exhibit potential for external NCTH control. In addition, resuscitative endovascular balloon occlusion of the aorta (REBOA) further provides an endovascular solution to alleviate the challenges of NCTH treatment. Notably, NCTH cognitive surveys have revealed that medical staff have deficiencies in understanding relevant concepts and treatment abilities. The stereotypical interpretation of NCTH naming, particularly the term noncompressible, is the root cause of this issue. This review discusses the dynamic relationship between TH and NCTH by tracing the development of external NCTH control techniques. The authors propose to further subdivide the existing NCTH into compressible torso hemorrhage and NCTH' (noncompressible but REBOA controllable) based on whether hemostasis is available via external compression. Finally, due to the irreplaceability of special tourniquets during the prehospital stage, the authors emphasize the importance of a package program to improve the efficacy and safety of external NCTH control. This program includes the promotion of tourniquet redesign and hemostatic strategies, personnel reeducation, and complications prevention.

摘要

由于肢体出血已通过四肢止血带得到很好的控制,因此在外伤性胸部出血(TH)的管理方面,无论是在军事医学还是民用医学领域都成为了一个热点问题。由于解剖学特征,常规止血技术对于控制胸内器官和血管的创伤性出血无效。非可压缩性胸出血(NCTH)的指定标志着在研究损伤机制和开发有效止血方法方面迈出了重要一步。专门为 NCTH 设计的腹主动脉和结部止血带和 SAM 结部止血带等特殊止血带已获得 FDA 批准用于临床使用。用于外部 NCTH 控制的 ready clamp 和 junctional emergency treatment tool 也具有潜在的应用前景。此外,复苏性血管内主动脉球囊阻断(REBOA)进一步为缓解 NCTH 治疗挑战提供了血管内解决方案。值得注意的是,NCTH 认知调查显示,医务人员在理解相关概念和治疗能力方面存在不足。对 NCTH 命名的刻板解释,尤其是“非可压缩性”一词,是造成这一问题的根本原因。本综述通过追踪外部 NCTH 控制技术的发展,讨论了 TH 和 NCTH 之间的动态关系。作者建议根据是否通过外部压迫实现止血,将现有的 NCTH 进一步细分为可压缩性胸出血和 NCTH'(不可压缩但可通过 REBOA 控制)。最后,由于在院前阶段特殊止血带的不可替代性,作者强调了改进外部 NCTH 控制的功效和安全性的一揽子计划的重要性。该方案包括促进止血带重新设计和止血策略、人员再教育以及预防并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/3a2b2da6aa9b/40001_2024_1760_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/7f178a2b65a7/40001_2024_1760_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/b5ae594b4124/40001_2024_1760_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/0aa67dc7d150/40001_2024_1760_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/6b7e6bae4e73/40001_2024_1760_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/3a2b2da6aa9b/40001_2024_1760_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/7f178a2b65a7/40001_2024_1760_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/b5ae594b4124/40001_2024_1760_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/0aa67dc7d150/40001_2024_1760_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/6b7e6bae4e73/40001_2024_1760_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b59/10919054/3a2b2da6aa9b/40001_2024_1760_Fig5_HTML.jpg

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本文引用的文献

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JAMA. 2023 Nov 21;330(19):1862-1871. doi: 10.1001/jama.2023.20850.
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Prehospital Resuscitation: What Should It Be?院前复苏:应该是什么?
Adv Surg. 2023 Sep;57(1):233-256. doi: 10.1016/j.yasu.2023.04.005. Epub 2023 Jun 1.
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An online survey of non-compressible torso hemorrhage: training is needed.
一项关于不可压缩躯干出血的在线调查:培训是必要的。
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Knowledge, attitude, and practice of artificial intelligence in emergency and trauma surgery, the ARIES project: an international web-based survey.人工智能在急诊和创伤外科中的知识、态度和实践,ARIES 项目:一项国际网络调查。
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Modulating Nanoparticle Size to Understand Factors Affecting Hemostatic Efficacy and Maximize Survival in a Lethal Inferior Vena Cava Injury Model.调控纳米颗粒大小以理解影响止血效果的因素并最大限度提高致命下腔静脉损伤模型中的存活率。
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Percutaneous delivery of self-propelling hemostatic powder for managing non-compressible abdominal hemorrhage: a proof-of-concept study in swine.经皮输送自推进止血粉治疗非压迫性腹部出血:猪体内的概念验证研究。
Injury. 2022 May;53(5):1603-1609. doi: 10.1016/j.injury.2022.01.024. Epub 2022 Jan 15.
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Ten-year reduction in thoracic injury-related mortality among Israel Defense Forces soldiers.以色列国防军士兵胸部损伤相关死亡率的十年降幅。
BMJ Mil Health. 2023 Nov 22;169(6):510-516. doi: 10.1136/bmjmilitary-2021-001986.
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Association between the time to definitive care and trauma patient outcomes: every minute in the golden hour matters.及时获得确定性治疗与创伤患者结局的关联:黄金一小时内的每一分钟都很重要。
Eur J Trauma Emerg Surg. 2022 Aug;48(4):2709-2716. doi: 10.1007/s00068-021-01816-8. Epub 2021 Nov 25.
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Red Alert: It Is Time to Strengthen the Medical Knowledge of Noncompressible Torso Hemorrhage Among Health-Care Workers.红色警报:医护人员急需强化非胸部压迫性出血的医学知识。
Disaster Med Public Health Prep. 2022 Oct;16(5):2020-2028. doi: 10.1017/dmp.2021.273. Epub 2021 Oct 18.
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Hemostatic shape memory polymer foams with improved survival in a lethal traumatic hemorrhage model.具有改善的生存能力的止血形状记忆聚合物泡沫在致命创伤性出血模型中。
Acta Biomater. 2022 Jan 1;137:112-123. doi: 10.1016/j.actbio.2021.10.005. Epub 2021 Oct 13.