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麻醉品成瘾及戒断机制的分析与研究。

Analysis and study of the mechanism of narcotic addiction and withdrawal.

作者信息

Wang Yan, Ke Jiawei, Li Shanshan, Kong Qingling, Zhang Mingyue, Li Mingming, Gu Jing, Chi Meng

机构信息

Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.

出版信息

Heliyon. 2024 Feb 27;10(5):e26957. doi: 10.1016/j.heliyon.2024.e26957. eCollection 2024 Mar 15.

Abstract

Narcotic drugs refer to drugs that have anesthetic effects on the central nervous system, and they easily produce physical dependence and mental dependence and can be addictive due to continuous use, abuse or unreasonable use. In this paper, bioinformatics and data analysis and mining techniques were used to analyze the methylation differences in transcriptional and clinical data of narcotic addiction in public databases, to explore the mechanism of narcotic addiction, and to mine some norepinephrine drugs. This study confirmed the possibility of using norepinephrine as an auxiliary drug for drug addiction rehabilitation. In addition, we also conducted a similar analysis on the addiction of three drugs. The results showed that the differences in the body caused by the ingestion of opiates and cocaine were significantly greater than those caused by the ingestion of methamphetamine.

摘要

麻醉药品是指对中枢神经系统有麻醉作用,连续使用、滥用或不合理使用易产生身体依赖性和精神依赖性,能成瘾癖的药品。本文利用生物信息学及数据分析挖掘技术,分析公共数据库中麻醉成瘾转录和临床数据的甲基化差异,探究麻醉成瘾机制,并挖掘一些去甲肾上腺素类药物。本研究证实了使用去甲肾上腺素作为药物成瘾康复辅助药物的可能性。此外,我们还对三种药物的成瘾情况进行了类似分析。结果表明,摄入阿片类药物和可卡因对身体造成的差异明显大于摄入甲基苯丙胺所造成的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ca/10915384/faf60849fbef/gr1.jpg

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