Tang Rongzhu, Gong Siyuan, Li Jia, Hu Wangjuan, Liu Jihong, Liao Chunlian
Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Neurosci. 2024 Feb 21;18:1337616. doi: 10.3389/fnins.2024.1337616. eCollection 2024.
Sleep disorders are one of the most common non-motor symptoms in PD. It can cause a notable decrease in quality of life and functioning in PD patients, as well as place a huge burden on both patients and caregivers. Currently, there are numerous non-pharmacological interventions available to improve sleep quality in PD, with disagreement as to which intervention is most effective. This network meta-analysis was performed to compare and rank non-pharmacological interventions to explore their efficacy in improving sleep quality in PD and to select the best interventions, with a view to providing references and bases for the development of clinical treatments and care programs.
The PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases were searched from inception to December 6, 2023. Two authors independently screened all studies, extracted the data, and evaluated risk of bias of included studies. STATA software version 17.0 was used to conduct the network meta-analysis.
Our network meta-analysis included 29 studies involving 1,477 participants and 16 non-pharmacological interventions. Although most nonpharmacological interventions showed non-significant effects, the surface under the cumulative ranking curve (SUCRA) values indicated that the best non-pharmacological intervention for sleep disorders was massage therapy (97.3%), followed by music therapy (94.2%), and Treadmill training (85.7%).
Massage therapy can be considered as an effective therapy for improving sleep quality in patients with PD. Due to limited quantity and quality of the included studies, more high quality studies are required to verify the conclusions of this network meta-analysis.
identifier CRD42023429339, PROSPERO (york.ac.uk).
睡眠障碍是帕金森病（PD）最常见的非运动症状之一。它会导致PD患者的生活质量和功能显著下降，同时给患者及其照顾者带来巨大负担。目前，有许多非药物干预措施可用于改善PD患者的睡眠质量，但对于哪种干预措施最有效存在分歧。进行这项网状Meta分析是为了比较和排序非药物干预措施，以探讨它们改善PD患者睡眠质量的疗效，并选择最佳干预措施，为临床治疗和护理方案的制定提供参考和依据。
检索了PubMed、Embase、Cochrane对照试验中心注册库（CENTRAL）、科学网、中国知网（CNKI）和万方数据库，检索时间从建库至2023年12月6日。两位作者独立筛选所有研究，提取数据，并评估纳入研究的偏倚风险。使用STATA软件17.0版进行网状Meta分析。
我们的网状Meta分析纳入了29项研究，涉及1477名参与者和16种非药物干预措施。尽管大多数非药物干预措施显示出不显著的效果，但累积排序曲线下面积（SUCRA）值表明，治疗睡眠障碍的最佳非药物干预措施是按摩疗法（97.3%），其次是音乐疗法（94.2%）和跑步机训练（85.7%）。
按摩疗法可被视为改善PD患者睡眠质量的有效疗法。由于纳入研究的数量和质量有限，需要更多高质量的研究来验证这项网状Meta分析的结论。
标识符CRD42023429339，PROSPERO（york.ac.uk）。
