Guo Yuxian, Che Ruochen, Wang Peipei, Zhang Aihua
Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, People's Republic of China.
Am J Physiol Renal Physiol. 2024 May 1;326(5):F768-F779. doi: 10.1152/ajprenal.00189.2023. Epub 2024 Mar 7.
Mitochondria are essential organelles in the human body, serving as the metabolic factory of the whole organism. When mitochondria are dysfunctional, it can affect all organs of the body. The kidney is rich in mitochondria, and its function is closely related to the development of kidney diseases. Studying the relationship between mitochondria and kidney disease progression is of great interest. In the past decade, scientists have made inspiring progress in investigating the role of mitochondria in the pathophysiology of renal diseases. This article discusses various mechanisms for maintaining mitochondrial quality, including mitochondrial energetics, mitochondrial biogenesis, mitochondrial dynamics, mitochondrial DNA repair, mitochondrial proteolysis and the unfolded protein response, mitochondrial autophagy, mitochondria-derived vesicles, and mitocytosis. The article also highlights the cross talk between mitochondria and other organelles, with a focus on kidney diseases. Finally, the article concludes with an overview of mitochondria-related clinical research.
线粒体是人体中至关重要的细胞器，充当着整个机体的代谢工厂。当线粒体功能失调时，会影响身体的所有器官。肾脏富含线粒体，其功能与肾脏疾病的发展密切相关。研究线粒体与肾脏疾病进展之间的关系极具意义。在过去十年中，科学家们在研究线粒体在肾脏疾病病理生理学中的作用方面取得了鼓舞人心的进展。本文讨论了维持线粒体质量的各种机制，包括线粒体能量代谢、线粒体生物发生、线粒体动力学、线粒体DNA修复、线粒体蛋白水解与未折叠蛋白反应、线粒体自噬、线粒体衍生囊泡和线粒体分裂。本文还强调了线粒体与其他细胞器之间的相互作用，重点是肾脏疾病。最后，本文对线粒体相关的临床研究进行了概述。
