声化学辅助合成 Zr-MOF/g-CN 修饰电极用于生物样品中超灵敏检测抗精神病药物氯普噻吨。
Design of sonochemical assisted synthesis of Zr-MOF/g-CN-modified electrode for ultrasensitive detection of antipsychotic drug chlorpromazine from biological samples.
机构信息
Department of Chemistry, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, 600 048, India.
Department of Chemical Engineering & Biotechnology, National Taipei University of Technology, Taipei, 10608, Taiwan.
出版信息
Mikrochim Acta. 2024 Mar 7;191(4):182. doi: 10.1007/s00604-024-06253-z.
The rapid fabrication is described of binary electrocatalyst based on a highly porous metal-organic framework with zirconium metal core (Zr-MOF) decorated over the graphitic carbon nitride (g-CN) nanosheets via facile ultrasonication method. It is used for the robust determination of antipsychotic drug chlorpromazine (CLP) from environmental samples. The electrochemical behaviour of 2D Zr-MOF@g-CN was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) studies. The crystalline and porous nature of the composite was characterized by XRD and SEM analysis. The functional groups and surface characteristics were investigated by FT-IR, Raman and XPS. The major electrochemical properties of the Zr-MOF@g-CN composite towards CLP detection were analyzed by CV, chronocoulometric (CC), chronoamperometric (CA) and differential pulse voltammetry (DPV) techniques. The composite exhibits a low detection limit (LOD) of 2.45 nM with a linear range of 0.02 to 2.99 µM and attractive sensitivity for CLP. The sensor system shows higher selectivity towards the possible interferences of CLP drug and exhibits better repeatability and stability. Finally, the fabricated sensor system shows a high recovery range varying from 96.2 to 98.9% towards the real samples. The proposed electrochemical probe might be a promising alternative to the prevailing diagnostic tools for the detection of CLP.
采用简便的超声法，在石墨相氮化碳（g-CN）纳米片上快速制备了基于高多孔金属有机骨架的二元电催化剂，其核心为锆金属（Zr-MOF）。该电催化剂用于从环境样品中稳健地测定抗精神病药物氯普噻吨（CLP）。通过循环伏安法（CV）和电化学阻抗谱（EIS）研究了二维 Zr-MOF@g-CN 的电化学行为。通过 XRD 和 SEM 分析对复合材料的结晶和多孔性质进行了表征。通过 FT-IR、拉曼和 XPS 研究了官能团和表面特性。通过 CV、计时库仑（CC）、计时安培（CA）和差分脉冲伏安法（DPV）技术分析了 Zr-MOF@g-CN 复合材料对 CLP 检测的主要电化学性质。该复合材料对 CLP 的检测具有低检测限（LOD）为 2.45 nM，线性范围为 0.02 至 2.99 µM，对 CLP 具有吸引力的灵敏度。该传感器系统对 CLP 药物的可能干扰具有更高的选择性，并表现出更好的重复性和稳定性。最后，该制造的传感器系统对实际样品的回收率范围在 96.2%至 98.9%之间。该电化学探针可能是用于检测 CLP 的现有诊断工具的有前途的替代方法。
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