Department of Surgery, Division of Cardiac Surgery, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, USA.
Department of Cardiovascular and Thoracic Surgery, University of Louisville, 201 Abraham Flexner Way, Louisville, KY, 40202, USA.
J Artif Organs. 2024 Dec;27(4):335-344. doi: 10.1007/s10047-024-01436-0. Epub 2024 Mar 7.
The shortcomings of expense, power requirements, infection, durability, size, and blood trauma of current durable LVADs have been recognized for many years. The LVADs of tomorrow aspire to be fully implantable, durable, mitigate infectious risk, mimic the pulsatile nature of the native cardiac cycle, as well as minimize bleeding and thrombosis. Power draw, battery cycle lifespan and trans-cutaneous energy transmission remain barriers to completely implantable systems. Potential solutions include decreases in pump electrical draw, improving battery lifecycle technology and better trans-cutaneous energy transmission, potentially from Free-range Resonant Electrical Energy Delivery. In this review, we briefly discuss the history of LVADs and summarize the LVAD devices in the development pipeline seeking to address these issues.
长久以来,人们一直认识到当前耐用型 LVAD 的费用、功耗、感染、耐用性、体积和血液创伤等方面的缺点。未来的 LVAD 渴望实现完全植入、耐用、降低感染风险、模拟原生心脏周期的脉动特性,以及最大限度减少出血和血栓形成。功耗、电池循环寿命和经皮能量传输仍然是完全植入式系统的障碍。潜在的解决方案包括降低泵的电力消耗、改进电池生命周期技术和更好的经皮能量传输,可能来自自由范围谐振电能传输。在这篇综述中,我们简要讨论了 LVAD 的历史,并总结了正在开发中的旨在解决这些问题的 LVAD 设备。