Department of Ophthalmology, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Department of Ophthalmology, Rio Hortega University Hospital, Valladolid, Spain.
Arq Bras Oftalmol. 2024 Mar 4;87(2):e20220091. doi: 10.5935/0004-2749.2022-0091. eCollection 2024.
Hepatitis C virus infection may be implicated in 12.7% of ocular adnexal marginal zone lymphomas. We present the first case of an orbital-systemic mucosa-associated lymphoid tissue lymphoma that responded to hepatitis C virus medical treatment. A 62-year-old male with a right-sided orbital mass was diagnosed with stage IIA orbital marginal zone lymphoma in addition to hepatitis C virus infection based on clinical, imaging, laboratory, and histological examinations. The systemic and orbital responses were achieved 1 year after undergoing hepatitis C virus treatment with glecaprevir/pibrentasvir. The association between the hepatitis C virus infection and orbital-systemic mucosa-associated lymphoid tissue lymphoma is relevant. Accordingly, patients with orbital mucosa-associated lymphoid tissue lymphoma should be assessed for hepatitis C virus seroreactivity for therapeutic and prognostic purposes.
丙型肝炎病毒感染可能与 12.7%的眼部附属器边缘区淋巴瘤有关。我们报告了首例接受丙型肝炎病毒治疗后缓解的眼眶系统性黏膜相关淋巴组织淋巴瘤病例。一名 62 岁男性，右侧眼眶内有一肿块，根据临床、影像学、实验室和组织学检查，被诊断为 IIA 期眼眶边缘区淋巴瘤，同时患有丙型肝炎病毒感染。接受 glecaprevir/pibrentasvir 治疗丙型肝炎病毒 1 年后，患者的眼眶和全身症状均得到缓解。丙型肝炎病毒感染与眼眶系统性黏膜相关淋巴组织淋巴瘤之间存在相关性。因此，出于治疗和预后目的，应评估患有眼眶黏膜相关淋巴组织淋巴瘤的患者是否存在丙型肝炎病毒血清学反应。
