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汗液作为临床诊断用非侵入性生物标志物的来源:概述。

Sweat as a source of non-invasive biomarkers for clinical diagnosis: An overview.

机构信息

Department of Plastic and Reconstructive Surgery, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Department of Plastic and Aesthetic Surgery, Ningbo Hangzhou Bay Hospital, Zhejiang, China.

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.

出版信息

Talanta. 2024 Jun 1;273:125865. doi: 10.1016/j.talanta.2024.125865. Epub 2024 Mar 1.

Abstract

Sweat has excellent potential as one of the sources of non-invasive biomarkers for clinical diagnosis. It is relatively easy to collect and process and may contain different disease-specific markers and drug metabolites, making it ideal for various clinical applications. This article discusses the anatomy of sweat glands and their role in sweat production, as well as the history and development of multiple sweat sample collection and analysis techniques. Another primary focus of this article is the application of sweat detection in clinical disease diagnosis and other life scenarios. Finally, the limitations and prospects of sweat analysis are discussed.

摘要

汗水作为非侵入性生物标志物的来源之一,具有巨大的潜力,可用于临床诊断。它相对容易收集和处理,并且可能包含不同的疾病特异性标志物和药物代谢物,使其成为各种临床应用的理想选择。本文讨论了汗腺的解剖结构及其在汗液产生中的作用,以及多种汗液样本采集和分析技术的历史和发展。本文的另一个主要重点是汗液检测在临床疾病诊断和其他生活场景中的应用。最后,讨论了汗液分析的局限性和前景。

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