MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, United Kingdom; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, United Kingdom.
Diabetes Res Clin Pract. 2024 Apr;210:111607. doi: 10.1016/j.diabres.2024.111607. Epub 2024 Mar 6.
To investigate the associations between weight change patterns and 5-year incident non-diabetic hyperglycaemia (NDH), and glycated haemoglobin (HbA) levels among individuals who had overweight or obesity.
This longitudinal cohort study (N = 435) pooled data from a weight management trial. Participants were adults with a body mass index of ≥28 kg/m. They were categorised as "no weight loss", "maintainers", and "regainers" based on their weight at 3 months and 12 months after baseline. Multivariable logistic regression models and linear regressions were conducted to examine the associations.
Between 1-year and 5-year follow-ups, 77 participants developed NDH. We found no statistically significant association between weight change patterns and incident NDH at 5 years. Among weight loss maintainers, mean HbA was -0.15% (95% confidence intervals (CI): -0.22, -0.10) lower after 1 year and -0.15% (95% CI: -0.23, -0.06) lower after 5 years compared to the no weight loss group. There was no difference between weight loss regainers and no weight loss group in HbA levels.
Compared to those who did not lose weight, participants who maintained their weight loss had lower HbA levels after 1 year and 5 years, which highlights the importance of providing long-term support to prevent weight regain.
研究体重变化模式与超重或肥胖个体 5 年内新发非糖尿病高血糖（NDH）和糖化血红蛋白（HbA）水平之间的关系。
本纵向队列研究（N=435）汇总了一项体重管理试验的数据。参与者的体重指数（BMI）≥28 kg/m2。根据基线后 3 个月和 12 个月的体重，将他们分为“无体重减轻”、“维持者”和“复胖者”。采用多变量逻辑回归模型和线性回归分析来检验相关性。
在 1 年和 5 年的随访期间，有 77 名参与者发生了 NDH。我们没有发现体重变化模式与 5 年内新发 NDH 之间存在统计学显著关联。在体重减轻维持者中，与无体重减轻组相比，1 年后 HbA 平均降低了-0.15%（95%置信区间（CI）：-0.22，-0.10），5 年后降低了-0.15%（95% CI：-0.23，-0.06）。体重减轻而复胖者与无体重减轻者的 HbA 水平无差异。
与未减轻体重的患者相比，保持体重减轻的患者在 1 年和 5 年后 HbA 水平更低，这凸显了提供长期支持以预防体重反弹的重要性。
