Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Trends Mol Med. 2024 May;30(5):429-442. doi: 10.1016/j.molmed.2024.02.004. Epub 2024 Mar 7.
Glioma is a type of aggressive and incurable brain tumor. Patients with glioma are highly resistant to all types of therapies, including immunotherapies. Epigenetic reprogramming is a key molecular hallmark in tumors across cancer types, including glioma. Mounting evidence highlights a pivotal role of epigenetic regulation in shaping tumor biology and therapeutic responses through mechanisms involving both glioma cells and immune cells, as well as their symbiotic interactions in the tumor microenvironment (TME). In this review, we discuss the molecular mechanisms of epigenetic regulation that impacts glioma cell biology and tumor immunity in both a cell-autonomous and non-cell-autonomous manner. Moreover, we provide an overview of potential therapeutic approaches that can disrupt epigenetic-regulated tumor-immune symbiosis in the glioma TME.
神经胶质瘤是一种侵袭性和不可治愈的脑肿瘤。神经胶质瘤患者对包括免疫疗法在内的所有类型的治疗均具有高度抗性。表观遗传重编程是包括神经胶质瘤在内的各种癌症类型肿瘤中的关键分子标志。越来越多的证据强调了表观遗传调控在通过涉及神经胶质瘤细胞和免疫细胞的机制以及它们在肿瘤微环境 (TME) 中的共生相互作用来塑造肿瘤生物学和治疗反应方面的关键作用。在这篇综述中，我们讨论了影响神经胶质瘤细胞生物学和肿瘤免疫的表观遗传调控的分子机制，包括自主和非自主方式。此外，我们还概述了可能破坏神经胶质瘤 TME 中受表观遗传调控的肿瘤-免疫共生的治疗方法。
