Radiation and Nuclear Countermeasures Program/Division of Allergy, Immunology, and Transplantation/National Institute of Allergy and Infectious Diseases/National Institutes of Health (NIH), Rockville, Maryland.
Division of Biological and Physical Sciences/National Aeronautics and Space Administration, Houston, Texas.
Radiat Res. 2024 Apr 1;201(4):338-365. doi: 10.1667/RADE-24-00003.1.
The U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, Advanced Technologies in Radiation Research (ATRR), which focused on the use of advanced technologies under development or in current use to accelerate radiation research. This meeting report provides a comprehensive overview of the research presented at the workshop, which included an assembly of subject matter experts from government, industry, and academia. Topics discussed during the workshop included assessments of acute and delayed effects of radiation exposure using modalities such as clustered regularly interspaced short palindromic repeats (CRISPR) - based gene editing, tissue chips, advanced computing, artificial intelligence, and immersive imaging techniques. These approaches are being applied to develop products to diagnose and treat radiation injury to the bone marrow, skin, lung, and gastrointestinal tract, among other tissues. The overarching goal of the workshop was to provide an opportunity for the radiation research community to come together to assess the technological landscape through sharing of data, methodologies, and challenges, followed by a guided discussion with all participants. Ultimately, the organizers hope that the radiation research community will benefit from the workshop and seek solutions to scientific questions that remain unaddressed. Understanding existing research gaps and harnessing new or re-imagined tools and methods will allow for the design of studies to advance medical products along the critical path to U.S. Food and Drug Administration approval.
美国政府致力于维持一个强大的研究计划，支持一批调查辐射暴露生物效应的科学专家。2023 年 8 月 17 日和 18 日，美国国立卫生研究院过敏与传染病研究所的辐射与核对策计划与国立癌症研究所、美国国立卫生研究院、美国国家航空航天局和辐射损伤治疗网络合作，举办了一个名为“辐射研究中的先进技术（ATRR）”的研讨会，该研讨会的重点是利用正在开发或当前使用的先进技术来加速辐射研究。本会议报告提供了研讨会提出的研究的全面概述，其中包括来自政府、工业和学术界的主题专家的集合。研讨会讨论的主题包括使用基于聚类规则间隔短回文重复序列（CRISPR）的基因编辑、组织芯片、先进计算、人工智能和沉浸式成像技术等模式评估辐射暴露的急性和延迟效应。这些方法正被应用于开发诊断和治疗骨髓、皮肤、肺和胃肠道等组织辐射损伤的产品。研讨会的总体目标是为辐射研究界提供一个机会，通过分享数据、方法和挑战来评估技术格局，然后让所有参与者进行有指导的讨论。最终，组织者希望辐射研究界将受益于研讨会，并寻求解决尚未解决的科学问题的解决方案。了解现有研究差距，并利用新的或重新构想的工具和方法，将有助于设计研究，以推进沿着美国食品和药物管理局批准的关键路径的医疗产品。
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