School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China.
School of Medicine, Chongqing University, Chongqing, 400030, China.
Curr Med Sci. 2024 Apr;44(2):281-290. doi: 10.1007/s11596-024-2843-9. Epub 2024 Mar 8.
Recent studies have shown that cellular levels of polyamines (PAs) are significantly altered in neurodegenerative diseases. Evidence from in vivo animal and in vitro cell experiments suggests that the cellular levels of various PAs may play important roles in the central nervous system through the regulation of oxidative stress, mitochondrial metabolism, cellular immunity, and ion channel functions. Dysfunction of PA metabolism related enzymes also contributes to neuronal injury and cognitive impairment in many neurodegenerative diseases. Therefore, in the current work, evidence was collected to determine the possible associations between cellular levels of PAs, and related enzymes and the development of several neurodegenerative diseases, which could provide a new idea for the treatment of neurodegenerative diseases in the future.
最近的研究表明，多胺（PAs）的细胞水平在神经退行性疾病中发生了显著改变。来自体内动物和体外细胞实验的证据表明，各种 PAs 的细胞水平可能通过调节氧化应激、线粒体代谢、细胞免疫和离子通道功能在中枢神经系统中发挥重要作用。PA 代谢相关酶的功能障碍也导致许多神经退行性疾病中的神经元损伤和认知障碍。因此，在目前的工作中，收集了证据来确定 PAs 的细胞水平及其相关酶与几种神经退行性疾病发展之间的可能关联，这为未来神经退行性疾病的治疗提供了一个新的思路。
