Delfan Maryam, Saeidi Ayoub, Supriya Rashmi, Escobar Kurt A, Laher Ismail, Heinrich Katie M, Weiss Katja, Knechtle Beat, Zouhal Hassane
Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran.
Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran.
Nutr Metab (Lond). 2024 Mar 7;21(1):11. doi: 10.1186/s12986-024-00785-0.
This study investigated the combined effects of 12 weeks of high-intensity interval training (HIIT) and spirulina supplementation on adipokine levels, insulin resistance, anthropometric indices, and cardiorespiratory fitness in 44 obese males (aged 25-40 years). The participants were randomly assigned to one of four groups: control (CG), supplement (SG), training (TG), or training plus supplement (TSG). The intervention involved daily administration of either spirulina or a placebo and HIIT three times a week for the training groups. Anthropometric indices, HOMA-IR, VO, and circulating adipokines (asprosin and lipocalin2, omentin-1, irisin, and spexin) were measured before and after the 12-week intervention. Post-intervention analysis indicated differences between the CG and the three interventional groups for body weight, fat-free mass (FFM), percent body fat (%BF), HOMA-IR, and adipokine levels (p < 0.05). TG and SG participants had increased VO (p < 0.05). Spirulina supplementation with HIIT increased VO, omentin-1, irisin, and spexin, while causing decreases in lipocalin-2 and asprosin levels and improvements in body composition (weight, %fat), BMI, and HOMA-IR. Notably, the combination of spirulina and HIIT produced more significant changes in circulating adipokines and cardiometabolic health in obese males compared to either supplementation or HIIT alone (p < 0.05). These findings highlight the synergistic benefits of combining spirulina supplementation with HIIT, showcasing their potential in improving various health parameters and addressing obesity-related concerns in a comprehensive manner.
本研究调查了12周高强度间歇训练（HIIT）和补充螺旋藻对44名肥胖男性（年龄在25至40岁之间）的脂肪因子水平、胰岛素抵抗、人体测量指标和心肺适能的综合影响。参与者被随机分为四组之一：对照组（CG）、补充组（SG）、训练组（TG）或训练加补充组（TSG）。干预措施包括训练组每天服用螺旋藻或安慰剂，并每周进行三次HIIT。在为期12周的干预前后，测量了人体测量指标、稳态模型评估胰岛素抵抗（HOMA-IR）、最大摄氧量（VO₂）以及循环脂肪因子（阿扑脂蛋白、lipocalin2、网膜素-1、鸢尾素和信号肽）。干预后分析表明CG与三个干预组在体重、去脂体重（FFM）、体脂百分比（%BF）、HOMA-IR和脂肪因子水平方面存在差异（p<0.05）。TG和SG参与者的VO₂增加（p<0.05）。补充螺旋藻并结合HIIT可提高VO₂、网膜素-1、鸢尾素和信号肽水平，同时降低lipocalin-2和阿扑脂蛋白水平，并改善身体成分（体重、%脂肪）、体重指数（BMI）和HOMA-IR。值得注意的是，与单独补充螺旋藻或进行HIIT相比，螺旋藻与HIIT的组合在肥胖男性的循环脂肪因子和心脏代谢健康方面产生了更显著的变化（p<0.05）。这些发现突出了螺旋藻补充剂与HIIT相结合的协同益处，展示了它们在全面改善各种健康参数和解决肥胖相关问题方面的潜力。
