Department of Intensive Care, Leiden University Medical Center, Albinusdreef 2, Leiden, B4-57, 2333 ZA, the Netherlands.
Department of Pulmonology, Leiden University Medical Centre, Leiden, the Netherlands.
Respir Res. 2024 Mar 7;25(1):117. doi: 10.1186/s12931-024-02747-9.
Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pre- and post-surgery non-fiberscopic miniBAL fluids were analysed for MUC5AC, MUC5B, IL-8, human neutrophil elastase, and neutrophils. All measured biomarkers increased after surgery. Perioperative MUC5AC-change showed a significant negative association with postoperative P/F ratio (p = 0.018), and a positive association with ICU stay (p = 0.027). In conclusion, development of lung injury after cardiac surgery and prolonged ICU stay are associated with an early increase of MUC5AC as detected in mini-BAL.
心脏手术可能会导致急性肺损伤和成人呼吸窘迫综合征。据报道，在急性肺损伤中，肺部黏蛋白 MUC5AC 和 MUC5B 的表达和释放增加。我们的研究目的是：[1] 研究 mini-bronchoalveolar lavage (minBAL) 中 MUC5AC、MUC5B 和其他生物标志物的围手术期变化，[2] 将这些变化与心脏手术后的临床结果相关联。在这项前瞻性队列研究中，对 49 例成年心脏手术患者手术前后的非纤维镜 miniBAL 液进行了分析，以检测 MUC5AC、MUC5B、IL-8、人中性粒细胞弹性蛋白酶和中性粒细胞。所有测量的生物标志物在手术后均增加。围手术期 MUC5AC 的变化与术后 P/F 比呈显著负相关（p=0.018），与 ICU 停留时间呈正相关（p=0.027）。总之，心脏手术后肺损伤的发展和 ICU 停留时间的延长与 mini-BAL 中检测到的 MUC5AC 的早期增加有关。
