Sukkasame Pichamon, Jareemit Nida, Punyashthira Awassada, Inthasorn Perapong, Chantawong Nopwaree, Suwannarurk Komsun, Pariyawateekul Piyawan, Tangjitgamol Siriwan
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Obstet Gynecol Sci. 2024 May;67(3):286-295. doi: 10.5468/ogs.23293. Epub 2024 Mar 8.
To compare attitudes toward self-sampling for human papillomavirus (HPV) testing before and after specimen collection in women undergoing colposcopy. The factors associated with the pre-sampling attitude were also studied.
This prospective study enrolled women with abnormal cervical cytology and/or positive high-risk HPV who attended colposcopy clinics at 10 cancer centers in Thailand between October 2021 and May 2022. Prior to colposcopy, the attitudes of the women toward self-sampling were surveyed through a questionnaire. Written and verbal instructions for self-sampling were provided before the process and subsequent colposcopy. The attitudes toward self-sampling were reassessed after the actual self-sampling. Factors associated with the attitudes were analyzed.
A total of 499 women were included in this study. The mean age was 39.28±11.36 years. A total of 85.3% were premenopause, and 98.8% had sexual experience. With the full score of 45, the attitude score after self-sampling was significantly higher than the attitude score before self-sampling (39.69±5.16 vs. 37.76±5.71; P<0.001). On univariate analysis, the factors associated with attitude before HPV self-sampling were age, menopausal status, sexual activity, education level, income, knowledge regarding HPV, and prior high-grade squamous intraepithelial lesion histology. The remaining significant factor on multivariate analysis was sexual activity within the past year (B=0.105, 95% confidence interval, 0.014-2.870; P=0.048).
Attitudes toward self-sampling improved after the actual self-sampling process, as evidenced by higher attitude scores. Sexual activity was the only independent factor related to the attitude before self-sampling.
比较接受阴道镜检查的女性在样本采集前后对人乳头瘤病毒（HPV）检测自我采样的态度。同时研究与采样前态度相关的因素。
这项前瞻性研究纳入了2021年10月至2022年5月期间在泰国10个癌症中心阴道镜诊所就诊的宫颈细胞学异常和/或高危HPV阳性的女性。在阴道镜检查前，通过问卷调查这些女性对自我采样的态度。在自我采样过程及随后的阴道镜检查前，提供自我采样的书面和口头指导。在实际自我采样后重新评估对自我采样的态度。分析与态度相关的因素。
本研究共纳入499名女性。平均年龄为39.28±11.36岁。共有85.3%处于绝经前，98.8%有性经历。满分45分，自我采样后的态度得分显著高于自我采样前（39.69±5.16 vs. 37.76±5.71；P<0.001）。单因素分析显示，与HPV自我采样前态度相关的因素有年龄、绝经状态、性活动、教育水平、收入、HPV知识以及既往高级别鳞状上皮内病变组织学情况。多因素分析中，其余显著因素为过去一年内的性活动（B=0.105，95%置信区间，0.014 - 2.870；P=0.048）。
实际自我采样过程后对自我采样的态度有所改善，态度得分更高即证明了这一点。性活动是与自我采样前态度相关的唯一独立因素。
