Cassell Ayun, Konneh Solomane
Division of Urology, Department of Surgery, John F Kennedy Medical Center, Monrovia 100010, Liberia.
World J Clin Oncol. 2024 Feb 24;15(2):169-174. doi: 10.5306/wjco.v15.i2.169.
Prostate cancer poses a significant health challenge globally, demanding proactive prevention strategies. This editorial explores the emerging role of vitamin D in prostate cancer prevention. While traditionally associated with bone health, vitamin D is increasingly recognized for its broader impact on immune function, cellular signaling, and cancer prevention. Epidemiological studies suggest an intriguing link between vitamin D deficiency and elevated prostate cancer risk, particularly in regions with limited sunlight exposure. Mechanistically, vitamin D regulates cellular processes, inhibiting unchecked cancer cell growth and bolstering immune surveillance. Personalized prevention strategies, considering individual factors, are deemed essential for harnessing the full potential of vitamin D. To unlock this potential, the future calls for robust research, public awareness campaigns, dietary improvements, and vigilant medical guidance. Collaborative efforts are poised to pave the way toward a future where vitamin D stands as a sentinel in prostate cancer prevention, ushering in hope and improved health for men worldwide.
前列腺癌在全球范围内对健康构成重大挑战,需要积极的预防策略。这篇社论探讨了维生素D在前列腺癌预防中日益凸显的作用。虽然传统上认为维生素D与骨骼健康有关,但它对免疫功能、细胞信号传导和癌症预防的更广泛影响正越来越受到认可。流行病学研究表明,维生素D缺乏与前列腺癌风险升高之间存在着有趣的联系,尤其是在阳光照射有限的地区。从机制上讲,维生素D调节细胞过程,抑制癌细胞的无节制生长并加强免疫监视。考虑个体因素的个性化预防策略被认为对于充分发挥维生素D的潜力至关重要。为了释放这种潜力,未来需要进行强有力的研究、开展公众宣传活动、改善饮食并提供警惕的医学指导。合作努力有望为未来铺平道路,在这个未来中,维生素D将成为前列腺癌预防的哨兵,为全球男性带来希望并改善健康状况。