Eva Taslima Akter, Mamurat Husnum, Rahat Md Habibul Hasan, Hossen S M Moazzem
Department of Pharmacy, Faculty of Biological Science University of Chittagong Chittagong Bangladesh.
Food Sci Nutr. 2023 Dec 7;12(3):1749-1767. doi: 10.1002/fsn3.3867. eCollection 2024 Mar.
The medicinal potential of , a traditional medicinal plant, was investigated through in vivo and molecular docking studies. The ethyl acetate fraction of the plant's acetonic extract was subjected to various bioactivity tests to assess its analgesic, anxiolytic, and sedative effects on Swiss albino mice. Furthermore, we used GCMS to identify the bioactive chemicals in the extract's ethyl acetate fraction. The root and bulb extracts demonstrated significant analgesic activity in acetic acid-induced writhing, hot plate, and tail immersion tests in a dose-dependent manner when compared to the control. Again, the extract exhibited moderate anxiolytic activity in the elevated plus maze test at a dosage of 400 mg/kg body weight, while the root extract showed significant anxiolytic activity in the hole board test at the same dosage. Significant sedative activity was observed in the hole cross, open field, and rotarod tests at a dosage of 400 mg/kg. According to molecular docking studies, the extract has the potential to serve as an analgesic medication by reducing the enzymatic activity of cyclooxygenases 1 and 2. Overall, the findings suggest that has substantial therapeutic potential for the development of novel treatments for pain, anxiety, and sleep disorders.
通过体内和分子对接研究，对一种传统药用植物的药用潜力进行了调查。对该植物丙酮提取物的乙酸乙酯部分进行了各种生物活性测试，以评估其对瑞士白化小鼠的镇痛、抗焦虑和镇静作用。此外，我们使用气相色谱 - 质谱联用仪（GCMS）来鉴定提取物乙酸乙酯部分中的生物活性化学物质。与对照组相比，根提取物和鳞茎提取物在乙酸诱导的扭体试验、热板试验和尾部浸入试验中均表现出显著的剂量依赖性镇痛活性。同样，该提取物在剂量为400mg/kg体重时，在高架十字迷宫试验中表现出中度抗焦虑活性，而根提取物在相同剂量下在洞板试验中表现出显著的抗焦虑活性。在剂量为400mg/kg时，在洞交叉试验、旷场试验和转棒试验中观察到显著的镇静活性。根据分子对接研究，该提取物有可能通过降低环氧化酶1和2的酶活性来作为一种镇痛药物。总体而言，研究结果表明，该植物对于开发治疗疼痛、焦虑和睡眠障碍的新疗法具有巨大的治疗潜力。
