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越南感染情况的首次报告。

The First Report of Infection in Vietnam.

作者信息

Dang-Vu Thong, Lam-Quoc Dung, Duong-Minh Ngoc, Vu Ha, Nguyen-Ho Lam, Truong-Thien Phu, Nguyen-Dang Khoa

机构信息

Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam.

Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

出版信息

Eur J Case Rep Intern Med. 2024 Feb 12;11(3):004335. doi: 10.12890/2024_004335. eCollection 2024.

DOI:10.12890/2024_004335
PMID:38455702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10917409/
Abstract

UNLABELLED

Infection caused by ha s rapidly become a global health threat. created a significant healthcare burden due to various complicating factors, including misidentification by commercial identification methods, potent antifungal resistance, high mortality rates and the possibility of nosocomial outbreaks through direct contact. In Vietnam, there are currently no clinical reports on infections. Here, we present four clinical cases of infections in the Department of Pulmonary Medicine of Cho Ray Hospital in southern Vietnam. Through this report, we aim to highlight the attention to the emergence of in Vietnam. Further research on infections is warranted, focusing on newly observed clinical characteristics present in all cases in this report, including hypoalbuminaemia and corticosteroid usage. Moreover, one case of resistance to amphotericin B has been identified, possibly due to prior exposure to this antifungal agent.

LEARNING POINTS

Further research on infections is warranted, focusing on newly observed clinical features present in all cases in this report, including hypoalbuminaemia and corticosteroid use during hospitalisation.While remains susceptible to commonly used antifungal drugs, one case of resistance to amphotericin B has been documented, possibly due to prior exposure to this antifungal agent.

摘要

未标注

由[病原体名称]引起的感染迅速成为全球健康威胁。由于各种复杂因素,包括商业鉴定方法的误识别、强大的抗真菌耐药性、高死亡率以及通过直接接触导致医院感染爆发的可能性,它造成了巨大的医疗负担。在越南,目前尚无关于[病原体名称]感染的临床报告。在此,我们展示了越南南部乔雷医院肺病科的4例[病原体名称]感染临床病例。通过本报告,我们旨在强调对越南出现的[病原体名称]的关注。有必要对[病原体名称]感染进行进一步研究,重点关注本报告所有病例中出现的新观察到的临床特征,包括低白蛋白血症和使用皮质类固醇。此外,已发现1例对两性霉素B耐药的病例,可能是由于先前接触过这种抗真菌药物。

学习要点

有必要对[病原体名称]感染进行进一步研究,重点关注本报告所有病例中出现的新观察到的临床特征,包括住院期间的低白蛋白血症和使用皮质类固醇。虽然[病原体名称]对常用抗真菌药物仍敏感,但已记录到1例对两性霉素B耐药的病例,可能是由于先前接触过这种抗真菌药物。

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Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses.利用群体基因组分析追踪耳念珠菌的进化历史和全球扩张。
mBio. 2020 Apr 28;11(2):e03364-19. doi: 10.1128/mBio.03364-19.
3
Epidemiology, clinical characteristics, resistance, and treatment of infections by .……感染的流行病学、临床特征、耐药性及治疗情况
J Intensive Care. 2018 Oct 29;6:69. doi: 10.1186/s40560-018-0342-4. eCollection 2018.
4
Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally.耳念珠菌:全球医院获得性多重耐药真菌感染的一个迅速出现的病因。
PLoS Pathog. 2017 May 18;13(5):e1006290. doi: 10.1371/journal.ppat.1006290. eCollection 2017 May.
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Candida auris candidaemia in Indian ICUs: analysis of risk factors.印度重症监护病房中的耳念珠菌血症:危险因素分析
J Antimicrob Chemother. 2017 Jun 1;72(6):1794-1801. doi: 10.1093/jac/dkx034.
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Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses.全基因组测序和流行病学分析证实三大洲同时出现多重耐药性耳念珠菌
Clin Infect Dis. 2017 Jan 15;64(2):134-140. doi: 10.1093/cid/ciw691. Epub 2016 Oct 20.
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First report of Candida auris in America: Clinical and microbiological aspects of 18 episodes of candidemia.美国首次报告耳念珠菌感染:18 例念珠菌血症的临床和微生物学特征。
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Hidden killers: human fungal infections.隐形杀手:人类真菌感染。
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