Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Emerg Microbes Infect. 2022 Dec;11(1):1867-1875. doi: 10.1080/22221751.2022.2100280.
, a multidrug resistant pathogenic yeast, has spread worldwide and caused several outbreaks in healthcare settings. Here, we report the first case of candidemia in Taiwan in a patient with a two-month history of hospitalization in Vietnam. We performed further investigation on the isolate from the present case as well as the previously reported isolate identified from a wound in 2018 in Taiwan, which was the first case reported in Taiwan. Both isolates were found to be susceptible to fluconazole, amphotericin B, and echinocandins. Additionally, mutations in or were not detected in either isolate. Microsatellite genotyping revealed that both isolates belonged to the South Asian clade. In recent years, has emerged as a global concern, and differences in clades and susceptibility patterns mandate further awareness and systematic surveillance.
热带假丝酵母菌是一种多药耐药的致病性酵母，已在全球范围内传播，并在医疗保健环境中引发了几起暴发事件。在这里，我们报告了首例在越南住院两个月的患者发生的热带假丝酵母菌血症。我们对来自本病例的分离株以及 2018 年在台湾从伤口中分离出的首例报告病例中的 分离株进行了进一步的调查，这两株分离株均对氟康唑、两性霉素 B 和棘白菌素类药物敏感。此外，这两个分离株均未检测到 或 突变。微卫星基因分型显示，两株分离株均属于南亚分支。近年来，热带假丝酵母菌已成为一个全球性关注的问题，其在分支和药敏模式上的差异需要进一步的认识和系统监测。
