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2021年5月至10月在加拿大蒙特利尔的多个医疗中心发生的一起与使用超声凝胶有关的疫情。

A outbreak associated with the use of ultrasound gel in multiple healthcare centres in Montréal, Canada, May-October 2021.

作者信息

Arsenault Christine, Harel Josée, Doualla-Bell Florence, Cavayas Yiorgos Alexandros, Marchand-Sénécal Xavier, Frenette Charles, Longtin Yves, Lalande Linda, Diby L Marie-Paule, Desmarais Nadia

机构信息

Hôpital du Sacré-Cœur-de-Montréal, Montréal, QC.

Département de microbiologie, infectiologie et immunologie, Faculté de médecine, Université de Montréal, Montréal, QC.

出版信息

Can Commun Dis Rep. 2023 Aug 1;49(7-8):314-319. doi: 10.14745/ccdr.v49i78a03.

DOI:10.14745/ccdr.v49i78a03
PMID:38455880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10917130/
Abstract

BACKGROUND

is a non-fermenting, gram-negative bacteria that has previously been implicated in multiple nosocomial outbreaks through the use of contaminated medical devices and substances. This article reports on an outbreak of infections and colonizations, involving 11 patients from five acute care hospitals in Montréal, Canada.

METHODS

One sample was not available for testing, but the remaining 10 isolates (91%) were sent for phylogenetic testing. Medical materials and the patients' environments were also sampled and cultured. Samples were tested using pulsed field gel electrophoresis and multilocus sequence typing.

RESULTS

The outbreak was found to be associated with the use of intrinsically contaminated non-sterile ultrasound gel. Relatedness of the gel's and the patients' strains was demonstrated using gel electrophoresis and multilocus sequence typing analyses. The investigation was concluded with a prompt recall of the product, and the outbreak was declared over by the end of October 2021.

CONCLUSION

Contaminated non-sterile gel caused infections and pseudo-infections in several patients.

摘要

背景

是一种非发酵革兰氏阴性菌,此前曾因使用受污染的医疗设备和物质而引发多起医院感染暴发。本文报道了一起感染和定植暴发事件,涉及加拿大蒙特利尔五家急症护理医院的11名患者。

方法

有一份样本无法用于检测,但其余10株分离菌(91%)被送去进行系统发育检测。还对医疗材料和患者的环境进行了采样和培养。样本采用脉冲场凝胶电泳和多位点序列分型进行检测。

结果

发现此次暴发与使用本质上受污染的非无菌超声凝胶有关。通过凝胶电泳和多位点序列分型分析证明了凝胶菌株与患者菌株的相关性。调查以迅速召回该产品告终,疫情于2021年10月底宣布结束。

结论

受污染的非无菌凝胶在数名患者中引起了感染和假感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/10917130/5ee58db0ee4e/497803-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/10917130/5ee58db0ee4e/497803-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/10917130/5ee58db0ee4e/497803-f1.jpg

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Complex Bacteria: a Feared Contamination Risk in Water-Based Pharmaceutical Products.复杂细菌:水性药品中令人担忧的污染风险
Clin Microbiol Rev. 2020 Apr 15;33(3). doi: 10.1128/CMR.00139-19. Print 2020 Jun 17.
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Outbreak of Burkholderia cepacia bacteraemia in a tertiary care centre due to contaminated ultrasound probe gel.
三级护理中心因超声探头凝胶污染爆发洋葱伯克霍尔德菌菌血症
J Hosp Infect. 2018 Dec;100(4):e257-e258. doi: 10.1016/j.jhin.2018.04.014. Epub 2018 Apr 22.
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