Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Structure. 2024 Mar 7;32(3):258-260. doi: 10.1016/j.str.2024.01.009.
In this issue of Structure, Mahana et al. present their structural characterization of an annotated methyl-CpG-binding domain (MBD) from the histone H3 lysine 9 methyltransferase SETDB2. This study reveals that, rather than binding DNA as previously hypothesized, this domain instead interacts with a cystine-rich domain from C11orf46, highlighting its involvement in protein-protein interactions.
在本期《结构》杂志中，Mahana 等人对组蛋白 H3 赖氨酸 9 甲基转移酶 SETDB2 的注释甲基化 CpG 结合域（MBD）进行了结构表征。该研究表明，与之前假设的结合 DNA 不同，该结构域与来自 C11orf46 的富含半胱氨酸的结构域相互作用，突出了其在蛋白质-蛋白质相互作用中的参与。
