SETDB1: an emerging target for anticancer drug development.
作者信息
Trossini Gustavo Henrique Goulart, Hassanie Haifa, Penteado André Berndt, El-Hajje Marissa
机构信息
Laboratório de Integração entre Técnicas Experimentais e (LITEC), Computacionais no Planejamento de Fármacos, Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
出版信息
Future Med Chem. 2025 Jan;17(2):153-155. doi: 10.1080/17568919.2024.2444869. Epub 2024 Dec 25.
Abstract
摘要
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本文引用的文献
1
SETDB1 as a cancer target: challenges and perspectives in drug design.作为癌症靶点的SETDB1：药物设计中的挑战与前景
RSC Med Chem. 2024 Mar 19;15(5):1424-1451. doi: 10.1039/d3md00366c. eCollection 2024 May 22.
2
Cardiovascular disease and cancer: shared risk factors and mechanisms.心血管疾病和癌症：共同的风险因素和机制。
Nat Rev Cardiol. 2024 Sep;21(9):617-631. doi: 10.1038/s41569-024-01017-x. Epub 2024 Apr 10.
3
One form and two functions: MBD of SETDB2 is a protein-interacting domain.一种形式，两种功能：SETDB2 的 MBD 是一个蛋白相互作用结构域。
Structure. 2024 Mar 7;32(3):258-260. doi: 10.1016/j.str.2024.01.009.
4
Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.SETDB蛋白非经典甲基化CpG结合结构域与C11orf46之间蛋白质-蛋白质相互作用的结构证据。
Structure. 2024 Mar 7;32(3):304-315.e5. doi: 10.1016/j.str.2023.12.001. Epub 2023 Dec 29.
5
The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease.SETDB1 结构域分裂组蛋白赖氨酸甲基转移酶 1（SETDB1）在生物过程和疾病中的功能。
Epigenetics Chromatin. 2023 Dec 7;16(1):47. doi: 10.1186/s13072-023-00519-1.
6
Epigenetic basis of cancer drug resistance.癌症耐药性的表观遗传基础。
Cancer Drug Resist. 2020 Mar 19;3(1):113-116. doi: 10.20517/cdr.2020.06. eCollection 2020.
7
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance.建立 H3K9 甲基化异染色质及其在组织分化和维持中的功能。
Nat Rev Mol Cell Biol. 2022 Sep;23(9):623-640. doi: 10.1038/s41580-022-00483-w. Epub 2022 May 13.
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Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.APQ 通过调控 SETDB1 的活性改善亨廷顿病小鼠模型的异染色质凝聚、运动功能和神经病理学。
J Enzyme Inhib Med Chem. 2021 Dec;36(1):856-868. doi: 10.1080/14756366.2021.1900160.
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Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.结构导向发现强效且选择性的 SETDB1 结构域的细胞活性抑制剂。
Angew Chem Int Ed Engl. 2021 Apr 12;60(16):8760-8765. doi: 10.1002/anie.202017200. Epub 2021 Mar 8.
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Emerging role of tumor cell plasticity in modifying therapeutic response.肿瘤细胞可塑性在改变治疗反应中的新作用。
Signal Transduct Target Ther. 2020 Oct 7;5(1):228. doi: 10.1038/s41392-020-00313-5.
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