从抑制因子到增强剂：IL-10 在 CAR-T 细胞治疗实体瘤中的另一种作用。
From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors.
机构信息
School of Life Science and Technology, ShanghaiTech University, Shanghai, China; Lingang Laboratory, Shanghai 200031, China.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China; State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China; Shanghai Clinical Research and Trial Center, Shanghai, China.
出版信息
Cell Stem Cell. 2024 Mar 7;31(3):285-287. doi: 10.1016/j.stem.2024.02.003.
Aiming to improve the effector function of CAR-T cells, Zhao et al. report that IL-10 metabolically reprograms CAR-T cells, and this promotes their effectiveness against solid tumors and challenges IL-10's perceived role as merely immunosuppressive. This simple but promising strategy fosters durable immune memory and eagerly awaits validation in clinical trials.
为了提高嵌合抗原受体 T 细胞（CAR-T 细胞）的效应功能，Zhao 等人报告称，白细胞介素 10（IL-10）通过代谢重编程 CAR-T 细胞，从而提高其对抗实体瘤的效果，并对 IL-10 仅仅具有免疫抑制作用这一观点提出挑战。这种简单但有前景的策略促进了持久的免疫记忆，迫切需要在临床试验中得到验证。
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