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术后六周患者报告结局能否预测腰椎减压术后的长期临床结局?

Do Six-Week Postoperative Patient-Reported Outcomes Predict Long-Term Clinical Outcomes Following Lumbar Decompression?

机构信息

Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois.

出版信息

World Neurosurg. 2024 May;185:e900-e906. doi: 10.1016/j.wneu.2024.02.149. Epub 2024 Mar 6.

Abstract

BACKGROUND

Little research has been done to evaluate the prognostic value of short-term postoperative patient-reported outcomes (PROs) on long-term PROs following lumbar decompression (LD). We evaluated the prognostic value of short-term PROs on long-term PROs through 2 years after LD.

METHODS

A single spine surgeon database was retrospectively queried for patients undergoing primary LD with 6-week postoperative PROs reported. The demographics, perioperative traits, and preoperative, 6-month, 1-year, and 2-year PROs were recorded. The PROs included the visual analog scale (VAS) for back pain, VAS for leg pain, PRO measure information system for physical function (PROMIS-PF), and Oswestry disability index. Two-step multivariate linear regression was performed to determine the predictive value of 6-week PROs for the 6-month, 1-year, and 2-year PROs.

RESULTS

A total of 277 patients were included. The 6-week Oswestry disability index, VAS for leg pain, and 9-item patient health questionnaire (PHQ-9) are all positive predictors for their respective outcomes at 6 months. Additionally, the 6-week PROMIS-PF was a negative predictor of the 6-month PHQ-9. The 6-week PROMIS-PF positively predicted the PROMIS-PF through 1 year, and the PHQ-9 was a positive predictor of the PHQ-9 at 1 and 2 years postoperatively.

CONCLUSIONS

The 6-week postoperative PROs are predictive of the same outcomes at 6 months, the PROMIS-PF is predictive through 1 year, and the PHQ-9 is predictive through 2 years. Determining the predictive value of early postoperative PROs can be helpful in understanding the likely postoperative trajectory following LD and informing patient expectations.

摘要

背景

针对腰椎减压术后短期患者报告结局(PRO)对长期 PRO 的预后价值,研究甚少。我们通过腰椎减压术后 2 年,评估了短期 PRO 对长期 PRO 的预后价值。

方法

回顾性查询了单名脊柱外科医生数据库,纳入了术后 6 周报告 PRO 的初次腰椎减压术患者。记录了患者的人口统计学、围手术期特征以及术前、术后 6 个月、1 年和 2 年的 PRO。PRO 包括:腰背疼痛视觉模拟量表(VAS)、腿部疼痛 VAS、PRO 测量信息系统身体机能(PROMIS-PF)和 Oswestry 残疾指数。采用两步多元线性回归分析,确定术后 6 周 PRO 对术后 6 个月、1 年和 2 年 PRO 的预测价值。

结果

共纳入 277 例患者。术后 6 周 Oswestry 残疾指数、腿部疼痛 VAS 和 9 项患者健康问卷(PHQ-9)均为术后 6 个月时各自结局的正预测因子。此外,术后 6 周 PROMIS-PF 是术后 6 个月 PHQ-9 的负预测因子。术后 6 周 PROMIS-PF 对术后 1 年的 PROMIS-PF 呈正预测,PHQ-9 对术后 1 年和 2 年的 PHQ-9 呈正预测。

结论

术后 6 周的 PRO 可预测术后 6 个月时的相同结局,PROMIS-PF 可预测术后 1 年,PHQ-9 可预测术后 2 年。确定早期术后 PRO 的预测价值有助于了解腰椎减压术后的可能术后轨迹,并为患者提供期望。

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