Li Konstantin, Dzhumabekov Auyeskhan, Dyusembekov Yermek, Nurbakyt Ardak, Glushkova Natalya
Department of Population Health and Social Sciences, Kazakhstan Medical University "KSPH", Almaty, Kazakhstan.
Department of Clinical Work, Kazakhstan Medical University "KSPH", Almaty, Kazakhstan.
PLoS One. 2025 May 7;20(5):e0322123. doi: 10.1371/journal.pone.0322123. eCollection 2025.
Lumbar degenerative disc disease (DDD) is a prevalent musculoskeletal disorder characterized by significant pain, disability, and reduced quality of life. Depression frequently coexists with chronic pain conditions, intensifying symptoms and complicating management. Despite its clinical relevance, the prevalence of depression specifically among patients with lumbar DDD remains inadequately understood.
This systematic review and meta-analysis aimed to assess the prevalence of depression among patients with lumbar DDD and to identify potential sources of heterogeneity.
A comprehensive literature search was conducted using PubMed, Web of Science, ScienceDirect, Academic Search Complete, and Google Scholar to identify relevant studies published between 2015 and 2022. Studies reporting the prevalence of depression among patients with lumbar DDD were included in the analysis. Pooled prevalence estimates were calculated using random-effects models, and subgroup analyses were performed to investigate sources of heterogeneity.
Seven studies met the inclusion criteria, encompassing 3485 patients with lumbar DDD. The pooled prevalence of depression was estimated at 20.19% (95% CI 8.94-39.46%). Subgroup analyses revealed significant variations in prevalence estimates across different geographic regions and assessment tools. Sensitivity analyses confirmed the robustness of the findings, while meta-regression analyses did not identify significant associations between prevalence rates and factors such as age or year of publication.
This study highlights a substantial burden of depression among patients with lumbar DDD, emphasizing the need for comprehensive mental health assessment and management in this population. The findings contribute to a better understanding of the psychological comorbidities associated with lumbar DDD and have implications for clinical practice and future research.
腰椎退行性椎间盘疾病（DDD）是一种常见的肌肉骨骼疾病，其特征为严重疼痛、功能障碍和生活质量下降。抑郁症常与慢性疼痛状况并存，会加剧症状并使治疗复杂化。尽管抑郁症在临床上具有相关性，但腰椎DDD患者中抑郁症的患病率仍未得到充分了解。
本系统评价和荟萃分析旨在评估腰椎DDD患者中抑郁症的患病率，并确定潜在的异质性来源。
使用PubMed、科学网、ScienceDirect、学术搜索完整版和谷歌学术进行全面的文献检索，以识别2015年至2022年期间发表的相关研究。分析纳入了报告腰椎DDD患者中抑郁症患病率的研究。使用随机效应模型计算合并患病率估计值，并进行亚组分析以调查异质性来源。
七项研究符合纳入标准，共纳入3485例腰椎DDD患者。抑郁症的合并患病率估计为20.19%（95%CI 8.94 - 39.46%）。亚组分析显示，不同地理区域和评估工具的患病率估计存在显著差异。敏感性分析证实了研究结果的稳健性，而荟萃回归分析未发现患病率与年龄或发表年份等因素之间存在显著关联。
本研究强调了腰椎DDD患者中抑郁症的沉重负担，强调了对该人群进行全面心理健康评估和管理的必要性。这些发现有助于更好地理解与腰椎DDD相关的心理合并症，并对临床实践和未来研究具有启示意义。
