Polymer Research Laboratory, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
Polymer Research Laboratory, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran; Department of Biosystem Engineering, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
Int J Biol Macromol. 2024 Apr;264(Pt 2):130653. doi: 10.1016/j.ijbiomac.2024.130653. Epub 2024 Mar 6.
Novel hydrogel beads based on nanocomposite with outstanding antibacterial and swelling capabilities have been successfully produced as an efficient drug carrier for potential drug delivery systems in wound healing applications. The beads were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and EDX-Mapping analysis. Then, using tetracycline hydrochloride (TCH) as a model drug system, they were studied in vitro for their potential efficiency as pH and temperature dependent sustained drug delivery carriers. Moreover, they were assessed in terms of porosity, swelling degree, encapsulation efficiency, and in vitro release kinetics. Beads released drugs at their highest levels under alkaline circumstances (pH = 8) and at a temperature of 39 °C, with a cumulative TCH release of 96.2 % at 36 h and in accordance with the Weibull kinetics model (R = 0.98). Additionally, the disc diffusion experiment demonstrated the strong antibacterial activity of the synthesized beads and offered a feasible and cost-effective wound dressing material for treating infected wounds.
成功制备了一种基于纳米复合材料的新型水凝胶珠，具有出色的抗菌和溶胀性能，可用作潜在药物输送系统的高效药物载体，应用于伤口愈合领域。采用傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）和 EDX-Mapping 分析对水凝胶珠进行了表征。然后，以盐酸四环素（TCH）为模型药物系统，研究了其作为 pH 和温度依赖性的持续药物输送载体的潜在效率。此外，还评估了其孔隙率、溶胀度、包封效率和体外释放动力学。在碱性条件（pH = 8）和 39°C 的温度下，水凝胶珠的药物释放水平最高，在 36 小时内 TCH 的累积释放率为 96.2%，符合 Weibull 动力学模型（R = 0.98）。此外，圆盘扩散实验证明了合成水凝胶珠具有较强的抗菌活性，为治疗感染性伤口提供了一种可行且具有成本效益的伤口敷料材料。
