Pu Jian, Chung Henry
College of Agriculture, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Department of Entomology, and Ecology, Evolution, and Behavior Program, Michigan State University, East Lansing, MI 48824, USA.
Curr Opin Insect Sci. 2024 Jun;63:101184. doi: 10.1016/j.cois.2024.101184. Epub 2024 Mar 6.
The continuous use of insecticides over the last eight decades has led to the development of resistance to these insecticides. Research in the last few decades showed that the mechanisms underlying resistance are diverse but can generally be classified under several modes of resistance such as target-site resistance, metabolic resistance, and penetration resistance. In this review, we highlight new discoveries in insecticide resistance research made over the past few years, including an emerging new mode of resistance, sequestration resistance, where the overexpression of olfactory proteins binds and sequesters insecticides in resistant strains, as well as recent research on how posttranscriptional regulation can impact resistance. Future research will determine the generality of these emerging mechanisms across insect species.
在过去八十年里持续使用杀虫剂已导致昆虫对这些杀虫剂产生抗性。过去几十年的研究表明，抗性背后的机制多种多样，但一般可归类为几种抗性模式，如靶标位点抗性、代谢抗性和穿透抗性。在本综述中，我们重点介绍了过去几年杀虫剂抗性研究中的新发现，包括一种新出现的抗性模式——隔离抗性，即嗅觉蛋白的过表达在抗性品系中结合并隔离杀虫剂，以及近期关于转录后调控如何影响抗性的研究。未来的研究将确定这些新出现的机制在昆虫物种中的普遍性。
