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膝关节和髋关节置换术后,最小重要变化阈值会随时间而改变。

Minimal important change thresholds change over time after knee and hip arthroplasty.

作者信息

Harris Lasse K, Troelsen Anders, Terluin Berend, Gromov Kirill, Ingelsrud Lina H

机构信息

Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Clin Epidemiol. 2024 May;169:111316. doi: 10.1016/j.jclinepi.2024.111316. Epub 2024 Mar 6.

Abstract

OBJECTIVES

The minimal important change (MIC) reflects what patients, on average, consider the smallest improvement in a score that is important to them. MIC thresholds may vary across patient populations, interventions used, posttreatment time points and derivation methods. We determine and compare MIC thresholds for the Oxford Knee Score and Oxford Hip Score (OKS/OHS) at 3 months postoperatively to 12- and 24-month thresholds in patients undergoing knee or hip arthroplasty.

STUDY DESIGN AND SETTING

This cohort study used data from patients undergoing total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), or total hip arthroplasty (THA) at a public hospital between February 2016 and February 2023. At 3, 12, and 24 months postoperatively, patients responded to the OKS/OHS and a 7-point anchor question determining experienced changes in knee or hip pain and functional limitations. We used the adjusted predictive modeling method that accounts for the proportion improved and the reliability of the anchor question to determine MIC thresholds and their mean differences between time points.

RESULTS

Complete data were obtained from 695/957 (73%), 1179/1703 (69%), and 1080/1607 (67%) patients undergoing TKA, 474/610 (78%), 438/603 (73%), and 355/507 (70%) patients undergoing UKA, and 965/1315 (73%), 978/1409 (69%), and 1059/1536 (69%) patients undergoing THA at 3, 12, and 24 months, respectively. The median age ranged from 68 to 70 years and 55% to 60% were females. The proportions improved ranged between 83% and 95%. The OKS/OHS MIC thresholds were 0.1, 4.2, and 5.1 for TKA, 1.8, 5.6, and 3.4 for UKA, and 1.3, 6.1, and 6.0 for THA at 3, 12, and 24 months postoperatively, respectively. The reliability ranged between 0.64 and 0.82, and the MIC values increased between three and 12 months but not between 12 and 24 months.

CONCLUSION

Any absence of deterioration in pain and function is considered important at 3 months after knee or hip arthroplasty. Increasing thresholds over time suggest patients raise their standards for what constitutes a minimal important improvement over the first postoperative year. Besides improving our understanding of patients' views on postoperative outcomes, these clinical thresholds may aid in interpreting registry-based treatment outcome evaluations.

摘要

目的

最小重要变化(MIC)反映了患者平均认为对其而言具有重要意义的分数上的最小改善。MIC阈值可能因患者群体、所采用的干预措施、治疗后时间点以及推导方法的不同而有所差异。我们确定并比较了接受膝关节或髋关节置换术的患者术后3个月时牛津膝关节评分和牛津髋关节评分(OKS/OHS)的MIC阈值与术后12个月和24个月时的阈值。

研究设计与背景

这项队列研究使用了2016年2月至2023年2月期间在一家公立医院接受全膝关节置换术(TKA)、单髁膝关节置换术(UKA)或全髋关节置换术(THA)的患者的数据。在术后3个月、12个月和24个月时,患者对OKS/OHS以及一个7分的锚定问题做出回应,该问题用于确定膝关节或髋关节疼痛及功能受限方面所经历的变化。我们使用了调整后的预测建模方法,该方法考虑了改善的比例以及锚定问题的可靠性,以确定MIC阈值及其在各时间点之间的平均差异。

结果

分别在术后3个月、12个月和24个月时,从695/957(73%)接受TKA的患者、474/610(78%)接受UKA的患者以及965/1315(73%)接受THA的患者中获得了完整数据;在术后3个月、12个月和24个月时,分别从1179/1703(69%)接受TKA的患者、438/603(73%)接受UKA的患者以及978/1409(69%)接受THA的患者中获得了完整数据;在术后3个月、12个月和24个月时,分别从1080/1607(67%)接受TKA的患者、355/507(70%)接受UKA的患者以及1059/1536(69%)接受THA的患者中获得了完整数据。患者的年龄中位数在68至70岁之间,女性占55%至60%。改善的比例在83%至95%之间。术后3个月、12个月和24个月时,TKA的OKS/OHS的MIC阈值分别为0.1、4.2和5.1;UKA的分别为1.8、5.6和3.4;THA的分别为1.3、6.1和6.0。可靠性在0.64至0.82之间,MIC值在3个月至12个月之间增加,但在12个月至24个月之间没有增加。

结论

膝关节或髋关节置换术后3个月时,疼痛和功能未出现任何恶化被认为是重要的。随着时间推移阈值增加表明患者在术后第一年对构成最小重要改善的标准有所提高。除了增进我们对患者对术后结果看法的理解外,这些临床阈值可能有助于解释基于登记处的治疗结果评估。

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