Department of Genetics, Sana Institute of Higher Education, Sari, Iran; USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran.
School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Prog Mol Biol Transl Sci. 2024;204:69-95. doi: 10.1016/bs.pmbts.2023.12.007. Epub 2024 Jan 24.
RNA therapy involves utilizing RNA-based molecules to control biological pathways, aiming to cure specific diseases. As our understanding of RNA functions and their roles has expanded, the application of RNA therapies has broadened to target various therapeutic points. This approach holds promise for treating a range of diseases, including kidney diseases. Therapeutic RNA can be employed to target specific genes or pathways implicated in the development of kidney conditions, such as inflammation, fibrosis, and oxidative stress. This review highlights the therapeutic potential of RNA-based therapies across different types of kidney diseases, encompassing infection, inflammation, nephrotoxicity, and ischemia/reperfusion injury. Furthermore, studies have pinpointed the specific kidney cells involved in RNA therapy. To address challenges hindering the potential impact of RNA-based drugs on their targets, nanotechnology is integrated, and RNA-loaded vehicles with ligands are explored for more efficient outcomes.
RNA 疗法涉及利用基于 RNA 的分子来控制生物途径，旨在治疗特定疾病。随着我们对 RNA 功能及其作用的理解不断扩展，RNA 疗法的应用已扩展到针对各种治疗靶点。这种方法有望治疗多种疾病，包括肾脏疾病。治疗性 RNA 可用于针对与肾脏疾病发展相关的特定基因或途径，例如炎症、纤维化和氧化应激。本综述强调了 RNA 疗法在不同类型肾脏疾病中的治疗潜力，包括感染、炎症、肾毒性和缺血/再灌注损伤。此外，研究还确定了参与 RNA 治疗的特定肾脏细胞。为了解决阻碍 RNA 药物对其靶标产生潜在影响的挑战，纳米技术被整合，并且正在探索载有配体的 RNA 装载载体以获得更有效的结果。
