较高的液体摄入量和较低的热量摄入：极低出生体重儿发生严重支气管肺发育不良的相关风险
Higher fluid and lower caloric intakes: associated risk of severe bronchopulmonary dysplasia in ELBW infants.
作者信息
Kolitz Danielle, Przystac Lynn, Tucker Richard, Oh William, Stonestreet Barbara S
机构信息
Department of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, RI, USA.
出版信息
J Perinatol. 2024 Jul;44(7):941-946. doi: 10.1038/s41372-024-01928-0. Epub 2024 Mar 8.
OBJECTIVE
To examine nutritional intake profiles and growth trajectories of extremely low birth weight (ELBW) infants who develop severe bronchopulmonary dysplasia (BPD).
STUDY DESIGN
Case-control study using multiple logistic regression analysis with generalized estimating equations (GEE) to adjust for matching.
RESULTS
Cumulative and mean fluid intakes were higher (p = 0.003) and caloric intakes lower (p < 0.0001) through week two in infants who developed severe BPD (n = 120) versus those without severe BPD (n = 104). Mean caloric intake through week 12 was lower in infants who developed severe BPD (102 ± 10.1 vs. 107 ± 8.5 kcal/kg/day, p < 0.0001). In the logistic regression models, lower mean caloric intake through week 12 was associated with increased risk of developing severe BPD. Linear growth reduced the odds of BPD by ~30% for each Z-score point.
CONCLUSIONS
Higher fluid and lower total caloric intakes and reductions in linear growth were independently associated with an increased risk of developing severe BPD in ELBW infants.
目的
研究发生重度支气管肺发育不良（BPD）的极低出生体重（ELBW）婴儿的营养摄入情况和生长轨迹。
研究设计
病例对照研究，采用多重逻辑回归分析和广义估计方程（GEE）进行匹配调整。
结果
与未发生重度BPD的婴儿（n = 104）相比，发生重度BPD的婴儿（n = 120）在第2周时的累积液体摄入量和平均液体摄入量更高（p = 0.003），而热量摄入量更低（p < 0.0001）。发生重度BPD的婴儿在第12周时的平均热量摄入量更低（102±10.1 vs. 107±8.5 kcal/kg/天，p < 0.0001）。在逻辑回归模型中，第12周时较低的平均热量摄入量与发生重度BPD的风险增加相关。线性生长每增加一个Z评分点，BPD的发病几率降低约30%。
结论
较高的液体摄入量、较低的总热量摄入量以及线性生长减缓与ELBW婴儿发生重度BPD的风险增加独立相关。
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