Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Chem Biodivers. 2024 May;21(5):e202400409. doi: 10.1002/cbdv.202400409. Epub 2024 Mar 28.
From Garcinia pedunculata Roxb. fruits, two undescribed aromatic compounds including a benzofuran and a depsidone derivative, and a new natural product, together with four known compounds were isolated. Through the analysis of spectroscopic data, high resolution mass spectrum and calculated nuclear magnetic resonance, their structures were determined. The α-glucosidase inhibitory activity of the isolates was evaluated. And compound 3 exhibited a moderate inhibitory effect on α-glucosidase. The molecular docking of compound 3 was performed to elucidate the interaction with α-glucosidase.
从藤黄属植物的果实中分离得到了两种未被描述的芳香族化合物，包括苯并呋喃和去甲二萜衍生物，以及一种新的天然产物，此外还分离得到了四种已知化合物。通过光谱数据分析、高分辨率质谱和计算核磁共振，确定了它们的结构。对分离得到的化合物进行了α-葡萄糖苷酶抑制活性评价，结果表明化合物 3 对α-葡萄糖苷酶具有中等抑制作用。进一步对化合物 3 与α-葡萄糖苷酶的相互作用进行了分子对接研究。
