FCRL3 的表达上调，并与系统性红斑狼疮患者调节性 T 细胞中的 TIGIT 表达密切相关。
FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus.
机构信息
Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
出版信息
Eur J Immunol. 2024 May;54(5):e2350739. doi: 10.1002/eji.202350739. Epub 2024 Mar 10.
PMID:38461541
Abstract
Using data from single-cell RNA sequencing and flow cytometry, we initially examined the expression of FCRL3, finding it to be elevated and positively associated with TIGIT expression in the regulatory T cells of patients with systemic lupus erythematosus. This also suggests that the co-expression of FCRL3 and TIGIT warrants further attention.
摘要
利用单细胞 RNA 测序和流式细胞术的数据，我们最初检查了 FCRL3 的表达，发现其在系统性红斑狼疮患者的调节性 T 细胞中升高，并与 TIGIT 的表达呈正相关。这也表明 FCRL3 和 TIGIT 的共表达值得进一步关注。
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