TIGIT 调节性 T 细胞与自身免疫性疾病的关系。
The relationship between TIGIT regulatory T cells and autoimmune disease.
机构信息
Department of Ophthalmology, University of Oklahoma Health Sciences Center, Dean McGee Eye Institute, Oklahoma City, OK, USA; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Dean McGee Eye Institute, Oklahoma City, OK, USA.
出版信息
Int Immunopharmacol. 2020 Jun;83:106378. doi: 10.1016/j.intimp.2020.106378. Epub 2020 Mar 12.
The role of regulatory T cells (Treg cell) in controlling autoimmune disease is an area of intense study. As such, the characterization and understanding the function of Treg markers has the potential to provide a considerable impact in developing treatments and understanding the pathogenesis of autoimmune diseases. One such inhibitory Treg cell marker that has been recently discovered is T cell immunoglobulin and ITIM domain (TIGIT). In this review, we discuss what is known about the expression and function of TIGIT on Treg cells, and we discuss the relationship between TIGIT expressing Treg cells and different autoimmune diseases such as atopic dermatitis, autoimmune thyroiditis, type 1 diabetes, autoimmune uveitis, aplastic anemia, multiple sclerosis, systemic lupus erythematosus, arthritis, and colitis.
调节性 T 细胞（Treg 细胞）在控制自身免疫性疾病中的作用是一个研究热点。因此，对 Treg 标志物的特征和功能的研究有可能对开发治疗方法和理解自身免疫性疾病的发病机制产生重大影响。最近发现的一种抑制性 Treg 细胞标志物是 T 细胞免疫球蛋白和 ITIM 结构域（TIGIT）。在这篇综述中，我们讨论了已知的 TIGIT 在 Treg 细胞上的表达和功能，以及 TIGIT 表达的 Treg 细胞与特应性皮炎、自身免疫性甲状腺炎、1 型糖尿病、自身免疫性葡萄膜炎、再生障碍性贫血、多发性硬化症、系统性红斑狼疮、关节炎和结肠炎等不同自身免疫性疾病之间的关系。
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