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一种新型的可视化医学诊断推理智能模型:以中医为例。

A novel intelligent model for visualized inference of medical diagnosis: A case of TCM.

机构信息

Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Nanhai Guicheng Hospital, Foshan 528221, China.

出版信息

Artif Intell Med. 2024 Mar;149:102799. doi: 10.1016/j.artmed.2024.102799. Epub 2024 Feb 8.

DOI:10.1016/j.artmed.2024.102799
PMID:38462291
Abstract

How to present an intelligent model based on known diagnostic knowledge to assist medical diagnosis and display the reasoning process is an interesting issue worth exploring. This study developed a novel intelligent model for visualized inference of medical diagnosis with a case of Traditional Chinese Medicine (TCM). Four classes of TCM's diagnosis composed of Yin deficiency, Liver Yin deficiency, Kidney Yin deficiency, and Liver-Kidney Yin deficiency were selected as research examples. According to the knowledge of diagnostic points in "Diagnostics of TCM", a total of 2000 samples for training and testing were randomly generated for the four classes of TCM's diagnosis. In addition, a total of 60 clinical samples were collected from hospital clinical cases. Training samples were sent to the pre-training language model of Chinese Bert for training to generate intelligent diagnostic module. Simultaneously, a mathematical algorithm was developed to generate inferential digraphs. In order to evaluate the performance of the model, the values of accuracy, F1 score, Mse, Loss and other indicators were calculated for model training and testing. And the confusion matrices and ROC curves were plotted to estimate the predictive ability of the model. The novel model was also compared with RF and XGBOOST. And some instances of inferential digraphs with the model were displayed and analyzed. It may be a new attempt to solve the problem of interpretable and inferential intelligent models in the field of artificial intelligence on medical diagnosis of TCM.

摘要

如何将基于已知诊断知识的智能模型呈现出来,辅助医学诊断并展示推理过程,是一个值得探索的有趣问题。本研究开发了一种新颖的智能模型,用于可视化中医(TCM)诊断推理。选择了由阴虚、肝阴虚、肾阴虚和肝肾阴虚组成的四类 TCM 诊断作为研究示例。根据“中医诊断学”中的诊断要点知识,为四类 TCM 诊断随机生成了总计 2000 个训练和测试样本。此外,还从医院临床病例中收集了总计 60 个临床样本。将训练样本发送到中文 Bert 的预训练语言模型进行训练,以生成智能诊断模块。同时,开发了一种数学算法来生成推理有向图。为了评估模型的性能,计算了模型训练和测试的准确率、F1 分数、Mse、Loss 等指标的值,并绘制了混淆矩阵和 ROC 曲线来估计模型的预测能力。还将新模型与 RF 和 XGBOOST 进行了比较,并展示和分析了模型的一些推理有向图实例。这可能是解决人工智能在 TCM 医学诊断领域中可解释和推理智能模型问题的一种新尝试。

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