Wang Chi, Zhang He, Nie Xin, Ding Fei, Liu Qianhui, Hou Lisha, Deng Yiping, Ye Wenbin, Yue Jirong, He Yong
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sichuan Clinical Research Center for Laboratory Medicine, Chengdu, Sichuan, China.
Front Public Health. 2024 Jul 24;12:1368933. doi: 10.3389/fpubh.2024.1368933. eCollection 2024.
Sarcopenia is a gradually advancing systemic disorder affecting skeletal muscles, primarily distinguished by diminished muscle mass and functional decline. As of present, a universally accepted diagnostic criterion for sarcopenia has yet to be established. From the perspective of the constitution theory in traditional Chinese medicine (TCM), the Yin-deficiency constitution is believed to have a significant correlation with the development of sarcopenia. The primary objective of this study was to examine the potential association between sarcopenia and Yin-deficiency constitution.
The present study is a cross-sectional analysis. The Asian Working Group for Sarcopenia (AWGS) recommended a diagnostic criterion for sarcopenia. A total of 141 participants over 50 years of age were diagnosed with sarcopenia. To determine the constitution of each patient, classification and determination standards were used in traditional Chinese medicine. In this study, a combination of logistic regression and propensity score matching (PSM) was employed to analyze a dataset comprising 1,372 eligible observations. The diagnostic efficacy of the test in distinguishing sarcopenia was assessed through receiver operating characteristic (ROC) curve analysis.
The relationship between Yin-deficiency constitution and sarcopenia was examined using logistic regression analysis. In the crude model, the odds ratio (OR) was found to be 3.20 (95% confidence interval [CI]: 1.70-6.03). After adjusting for various confounding factors, including gender, sex, 6 m walking test/(m/s), SMI, and maximum grip strength/kg, the OR increased to 9.70 (95% CI: 3.20-69.38). The associations between seven other biased traditional Chinese medicine (TCM) constitutions and sarcopenia were not found to be statistically significant in the fully adjusted model. The propensity score matching (PSM) analysis yielded consistent results with the logistic regression analysis. Receiver operating characteristic (ROC) curve analysis showed that the AUC of the Yin-deficiency constitution combined with age and gender reached 0.707.
Among the nine TCM constitutions examined, the Yin-deficiency constitution demonstrates an independent association with sarcopenia. Yin-deficiency constitution may serve as a potential risk factor for the development of sarcopenia. To establish a causal relationship, further experimental investigations are warranted. The diagnostic performance of sarcopenia is effectively demonstrated by the Yin-deficiency constitution combined with age and gender.
肌肉减少症是一种逐渐进展的影响骨骼肌的全身性疾病，主要特征为肌肉量减少和功能衰退。目前，尚未建立普遍接受的肌肉减少症诊断标准。从中医体质理论的角度来看，阴虚体质被认为与肌肉减少症的发生发展显著相关。本研究的主要目的是探讨肌肉减少症与阴虚体质之间的潜在关联。
本研究为横断面分析。亚洲肌肉减少症工作组（AWGS）推荐了肌肉减少症的诊断标准。共有141名50岁以上的参与者被诊断为肌肉减少症。为确定每位患者的体质，采用了中医的分类和判定标准。在本研究中，采用逻辑回归和倾向评分匹配（PSM）相结合的方法分析了包含1372个合格观察值的数据集。通过受试者工作特征（ROC）曲线分析评估该检测在区分肌肉减少症方面的诊断效能。
采用逻辑回归分析研究阴虚体质与肌肉减少症之间的关系。在粗模型中发现比值比（OR）为3.20（95%置信区间[CI]：1.70 - 6.03）。在调整了包括性别、6分钟步行试验速度（m/s）、骨骼肌指数（SMI）和最大握力/体重等各种混杂因素后，OR增加到9.70（95% CI：3.20 - 69.38）。在完全调整模型中，未发现其他七种偏颇中医体质与肌肉减少症之间的关联具有统计学意义。倾向评分匹配（PSM）分析与逻辑回归分析结果一致。受试者工作特征（ROC）曲线分析表明，阴虚体质联合年龄和性别时的曲线下面积（AUC）达到0.707。
在所研究的九种中医体质中，阴虚体质与肌肉减少症存在独立关联。阴虚体质可能是肌肉减少症发生发展的潜在危险因素。为建立因果关系，有必要进行进一步的实验研究。阴虚体质联合年龄和性别可有效体现肌肉减少症的诊断效能。
