Alexander Lind, Yang Cao, Hugo Hesser, Maria Hårdstedt, Stefan Jansson, Åke Lernmark, Martin Sundqvist, Staffan Tevell, Cheng-Ting Tsai, Jeanette Wahlberg, Johan Jendle
Department of Clinical Sciences Malmö, Lund University, Sweden.
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Diabet Epidemiol Manag. 2024 Jan-Mar;13. doi: 10.1016/j.deman.2023.100194. Epub 2023 Dec 15.
The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic.
Via randomization, individuals living with diabetes T1D (n= 203) and T2D (n=413), were identified during February-July 2021 through health-care registers. Population controls (n=282) were matched for age, gender, and residential area. Questionnaires included self-assessment of anxiety, depression, QoL, and demographics in relation to SARS-CoV-2 exposure.Blood was collected through home-capillary sampling, and SARS-CoV-2 Nucleocapsid (NCP) and Spike antibodies (SC2_S1) were determined by multiplex Antibody Detection by Agglutination-PCR (ADAP) assays.
Younger age and health issues were related to anxiety, depression, and QoL, with no differences between the study groups. Female gender was associated with anxiety, while obesity was associated with lower QoL.The SARS-CoV-2 NCP seroprevalence was higher in T1D (8.9%) compared to T2D (3.9%) and controls (4.0%), while the SARS-CoV-2 SC2_S1 seroprevalence was higher for controls (25.5%) compared to T1D (16.8%) and T2D (14.0%).
A higher SARS-CoV-2 infection rate in T1D may be explained by younger age and higher employment rate, and the associated increased risk for viral exposure.
本研究旨在比较在新冠疫情第二波期间，1型糖尿病（T1D）和2型糖尿病（T2D）患者与匹配对照组在焦虑、抑郁及生活质量（QoL）方面的差异。
通过随机化，于2021年2月至7月期间，利用医疗保健登记册确定了203例T1D患者和413例T2D患者。按年龄、性别和居住地区匹配了282名人群作为对照。问卷包括焦虑、抑郁、生活质量的自我评估以及与SARS-CoV-2暴露相关的人口统计学信息。通过家庭毛细血管采样采集血液，采用凝集-聚合酶链反应多重抗体检测（ADAP）法测定SARS-CoV-2核衣壳（NCP）和刺突抗体（SC2_S1）。
年龄较小和存在健康问题与焦虑、抑郁及生活质量相关，各研究组之间无差异。女性与焦虑相关，而肥胖与较低的生活质量相关。T1D患者的SARS-CoV-2 NCP血清阳性率（8.9%）高于T2D患者（3.9%）和对照组（4.0%），而对照组的SARS-CoV-2 SC2_S1血清阳性率（25.5%）高于T1D患者（16.8%）和T2D患者（14.0%）。
T1D患者中较高的SARS-CoV-2感染率可能与年龄较小、就业率较高以及相关的病毒暴露风险增加有关。
