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撤回:高通量CRISPR干扰筛选鉴定出影响原始生殖细胞发育的表观遗传调节因子。

WITHDRAWN: High throughput CRISPR perturbation screens identify epigenetic regulators impacting primordial germ cell development.

作者信息

Li Liangdao, Ding Xinbao, Sheft Alex P, Schimenti John C

出版信息

bioRxiv. 2025 May 13:2024.02.26.582097. doi: 10.1101/2024.02.26.582097.

Abstract

The authors have withdrawn this manuscript due this manuscript merging with another preprint (BIORXIV/2024/580543). Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. The merged preprint can be found at doi: 10.1101/2024.02.15.580543" The original version of 580543 described the development and characterization of the engineered mouse embryonic stem cells (ESCs) that could be differentiated into primordial germ cell-like cells (PGCLCs) in a scalable and efficient manner. Those cells were used to conduct the large screen (and other experiments) described in this withdrawn preprint. We merged the two manuscripts at the recommendation of a journal editor to which we sent the two papers for concurrent consideration. There are no substantive differences in the content merged preprint vs. this withdrawn preprint or the original version of 580543.

摘要

由于本稿件与另一篇预印本(BIORXIV/2024/580543)合并,作者撤回了本稿件。因此,作者不希望此作品被作为该项目的参考文献引用。如果您有任何疑问,请联系通讯作者。合并后的预印本可在doi: 10.1101/2024.02.15.580543找到。580543的原始版本描述了工程化小鼠胚胎干细胞(ESCs)的开发和特性,这些细胞能够以可扩展且高效的方式分化为原始生殖细胞样细胞(PGCLCs)。这些细胞被用于进行本撤回预印本中描述的大规模筛选(以及其他实验)。应期刊编辑的建议,我们将两篇稿件合并,我们同时将这两篇论文提交给该期刊编辑以供审议。合并后的预印本与本撤回预印本或580543的原始版本在内容上没有实质性差异。

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