Mazza Marianna, De Berardis Domenico, Marano Giuseppe
Department of Neurosciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Mental Health, NHS, ASL 4 Teramo, Teramo 64100, Italy.
World J Psychiatry. 2024 Feb 19;14(2):194-198. doi: 10.5498/wjp.v14.i2.194.
Women represent the majority of patients with psychiatric diagnoses and also the largest users of psychotropic drugs. There are inevitable differences in efficacy, side effects and long-term treatment response between men and women. Psychopharmacological research needs to develop adequately powered animal and human trials aimed to consider pharmacokinetics and pharmacodynamics of central nervous system drugs in both male and female subjects. Healthcare professionals have the responsibility to prescribe sex-specific psychopharmacotherapies with a priority to differentiate between men and women in order to minimize adverse drugs reactions, to maximize therapeutic effectiveness and to provide personalized management of care.
女性占精神疾病诊断患者的大多数,也是精神药物的最大使用者。男性和女性在疗效、副作用和长期治疗反应方面存在不可避免的差异。精神药理学研究需要开展有足够样本量的动物和人体试验,旨在考虑中枢神经系统药物在男性和女性受试者中的药代动力学和药效学。医疗保健专业人员有责任优先开具针对性别的精神药物治疗方案,以区分男性和女性,从而尽量减少药物不良反应,最大限度地提高治疗效果,并提供个性化的护理管理。