Rafaï Clotaire Donatien, Heredeibona Luc Salva, Lango-Yaya Ernest, Belizaire Roseline Darnicka, Senzongo Oscar, Mbala Placide, Fa-Ti-Gbia Maurel Ouoko, Bengba Javan Allon, Pounguinza Simon, Kandou Jephté Estimé Kaleb, Gonessa Daniel Yvon, Koyaweda Wilfried, Vickos Ulrich, Kalla Ginette Claude, Nambei Wilfried Sylvain, Somse Pierre, Bélec Laurent, Grésenguet Gérard, Koffi Boniface, Mbopi-Keou François-Xavier
Laboratoire National de Biologie Clinique et de Santé Publique, Bangui, République Centrafricaine.
Faculté des Sciences de la Santé, Université de Bangui, Centrafrique de la Santé et de la Population, Bangui, République Centrafricaine.
Pan Afr Med J. 2023 Dec 28;46:120. doi: 10.11604/pamj.2023.46.120.39511. eCollection 2023.
the National Laboratory of Clinical Biology and Public Health (NLBPH) in Bangui in the Central African Republic (CAR) carries out the vast majority of molecular screening tests for SARS-CoV-2 infection nationwide. This study aimed to show the contribution of molecular diagnosis and genomic surveillance in monitoring the evolution of longitudinal variations of the SARS-CoV-2 infection epidemic in CAR between 2020 and the end of 2022.
this is an observational study on the variations in the prevalence of detection of SARS-CoV-2 by RT-PCR at the NLCBPH from nasopharyngeal samples taken prospectively over a period of 3 years since the beginning of the COVID-19 epidemic. A subgroup of SARS-CoV-2 positive samples was selected for molecular sequencing performed by Illumina® and MinIon® at the National Institute for Biomedical Research in Kinshasa, Democratic Republic of the Congo.
from March 2020 to December 31, 2022, 88,442 RT-PCR tests were carried out (4/5 of the country) and detected 9,156 cases of SARS-CoV-2 infection in 5 successive waves. The average age of the patients was 39.8 years (extremes ranging from to 92 years). Age(P=0.001), sex(P=0.001) and symptom presentation(P=0.001) were significantly associated with RT-PCR test positivity. Among the different variants identified during successive waves, the Omicron variant predominated during the last two waves.
this prospective study over a period of 3 years, marked by 5 successive waves, made it possible to report that age, sex and the presence of clinical symptoms are associated with RT-PCR positivity. Among the different variants identified during successive waves, the Omicron variant predominated during the last two waves.
中非共和国班吉的国家临床生物学与公共卫生实验室（NLBPH）在全国范围内开展了绝大多数针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的分子筛查检测。本研究旨在展示分子诊断和基因组监测在监测2020年至2022年底中非共和国SARS-CoV-2感染疫情纵向变化演变中的作用。
这是一项关于自新冠疫情开始以来的3年期间，对NLBPH前瞻性采集的鼻咽样本进行逆转录聚合酶链反应（RT-PCR）检测SARS-CoV-2流行率变化的观察性研究。选择一组SARS-CoV-2阳性样本，由刚果民主共和国金沙萨的国家生物医学研究所使用Illumina®和MinIon®进行分子测序。
从2020年3月到2022年12月31日，共进行了88442次RT-PCR检测（占全国的五分之四），并在5次连续疫情波中检测到9156例SARS-CoV-2感染病例。患者的平均年龄为39.8岁（年龄范围从[未提及下限]到92岁）。年龄（P = 0.001）、性别（P = 0.001）和症状表现（P = 0.001）与RT-PCR检测阳性显著相关。在连续疫情波中鉴定出的不同变体中，奥密克戎变体在最后两次疫情波中占主导地位。
这项为期3年的前瞻性研究，以5次连续疫情波为特征，报告了年龄、性别和临床症状的存在与RT-PCR阳性相关。在连续疫情波中鉴定出的不同变体中，奥密克戎变体在最后两次疫情波中占主导地位。
