Wang Wenhong, Li Ke, Xiao Weihua
Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, China.
The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China.
J Ginseng Res. 2024 Mar;48(2):129-139. doi: 10.1016/j.jgr.2023.11.004. Epub 2023 Nov 15.
Liver diseases are a significant global health burden and are among the most common diseases. Ginssennoside Rg3 (Rg3), which is one of the most abundant ginsenosides, has been found to have significant preventive and therapeutic effects against various types of diseases with minimal side effects. Numerous studies have demonstrated the significant preventive and therapeutic effects of Rg3 on various liver diseases such as viral hepatitis, acute liver injury, nonalcoholic liver diseases (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC). The underlying molecular mechanism behind these effects is attributed to apoptosis, autophagy, antioxidant, anti-inflammatory activities, and the regulation of multiple signaling pathways. This review provides a comprehensive description of the potential molecular mechanisms of Rg3 in the development of liver diseases. The article focuses on the regulation of apoptosis, oxidative stress, autophagy, inflammation, and other related factors. Additionally, the review discusses combination therapy and liver targeting strategy, which can accelerate the translation of Rg3 from bench to bedside. Overall, this article serves as a valuable reference for researchers and clinicians alike.
肝脏疾病是一项重大的全球健康负担，也是最常见的疾病之一。人参皂苷Rg3（Rg3）是含量最为丰富的人参皂苷之一，已被发现对各类疾病具有显著的预防和治疗作用，且副作用极小。众多研究已证实Rg3对多种肝脏疾病具有显著的预防和治疗作用，如病毒性肝炎、急性肝损伤、非酒精性肝病（NAFLD）、肝纤维化和肝细胞癌（HCC）。这些作用背后的潜在分子机制归因于细胞凋亡、自噬、抗氧化、抗炎活性以及多种信号通路的调节。本综述全面描述了Rg3在肝脏疾病发生发展中的潜在分子机制。文章重点关注细胞凋亡、氧化应激、自噬、炎症及其他相关因素的调节。此外，该综述还讨论了联合治疗和肝脏靶向策略，这可以加速Rg3从实验室到临床应用的转化。总体而言，本文对研究人员和临床医生均具有重要的参考价值。
