Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia.
Antiviral Res. 2022 Jul;203:105345. doi: 10.1016/j.antiviral.2022.105345. Epub 2022 May 21.
In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.
除了严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV），SARS-CoV-2 已成为第三种感染人类并导致新型冠状病毒病（COVID-19）的致命冠状病毒。COVID-19 已在全球范围内造成超过 600 万人死亡，这很可能是人类本世纪面临的最大的大流行疾病。尽管已经对 SARS-CoV-2 进行了许多研究，但人们对 SARS-CoV-2 和 COVID-19 的了解仍不充分。动物模型对于研究其发病机制以及开发疫苗和抗病毒药物是不可或缺的。在这篇综述中，我们分析了冠状病毒感染的动物模型，并探讨了它们在抗病毒药物和疫苗方面的应用。
