Sharma Akshay, Kumar Pravesh, Sood Pankaj, Negi Vijender, Sharma Pururava
Department of Veterinary Gynecology and Obstetrics, DGCN College of Veterinary and Animal Sciences, CSK Himachal Pradesh Agriculture University, Palampur, India.
Vet Res Forum. 2024;15(2):83-88. doi: 10.30466/vrf.2023.2013227.4033. Epub 2024 Feb 15.
The present research was carried out to assess the serum progesterone (P) concentration and uterine hemodynamics at estrus till ovulation in cyclic cows (N = 130) with healthy or diseased uterus. At estrus, 85 cows were diagnosed with clinical endometritis (CE; n = 44) and sub-clinical endometritis (SCE; n = 41); whereas, 45 cows being served as control namely no endometritis (NE; n = 45) were included in the study. Serum progesterone estimation at 12 - 14 and 40 hr after the onset of estrus and Doppler sonography of both middle uterine arteries were done to envisage the uterine hemodynamics and ovulation. The serum progesterone concentration was significantly higher at 12 - 14 hr after onset of estrus in CE and SCE cows. At 12 - 14 hr after onset of estrus, a cut-off value of ≥ 0.48 ng mL P was obtained, above which 22.72% CE, 26.82% SCE and only 8.88% NE cows failed to ovulate within 36 - 40 hr of estrus onset. Among the Doppler indices, pulsatility and resistance indices were significantly higher; whereas, volume and velocity indices were significantly lower in NE cows. In cows diagnosed with CE and SCE, a higher supra-basal P concentration, and velocity and volume of blood flow to uterus at estrus negatively affected the duration to ovulation.
本研究旨在评估健康或患病子宫的周期性奶牛（N = 130）在发情期至排卵期间的血清孕酮（P）浓度和子宫血流动力学。在发情期，85头奶牛被诊断为临床子宫内膜炎（CE；n = 44）和亚临床子宫内膜炎（SCE；n = 41）；而45头作为对照即无子宫内膜炎（NE；n = 45）的奶牛被纳入研究。在发情开始后12 - 14小时和40小时测定血清孕酮，并对两条子宫中动脉进行多普勒超声检查，以观察子宫血流动力学和排卵情况。CE和SCE奶牛在发情开始后12 - 14小时的血清孕酮浓度显著更高。在发情开始后12 - 14小时，获得了≥ 0.48 ng/mL P的临界值，高于该值时，22.72%的CE奶牛、26.82%的SCE奶牛和仅8.88%的NE奶牛在发情开始后36 - 40小时内未能排卵。在多普勒指数中，NE奶牛的搏动性和阻力指数显著更高；而容积和速度指数显著更低。在诊断为CE和SCE的奶牛中，发情期较高的基础上孕酮浓度以及子宫血流速度和容积对排卵持续时间有负面影响。
