人白细胞弹性蛋白酶的蛋白水解失活
Proteolytic inactivation of human leukocyte elastase.
作者信息
Stein R L, Williams J C
出版信息
Experientia. 1985 May 15;41(5):638-40. doi: 10.1007/BF02007697.
PMID:3846535
Abstract
Human leukocyte elastase can be proteolytically inactivated by bovine pancreatic trypsin. Neither porcine pancreatic elastase nor bovine pancreatic chymotrypsin causes inactivation of leukocyte elastase, nor are trypsin, pancreatic elastase, or chymotrypsin themselves susceptible to proteolysis. The trypsin-catalyzed inactivation of leukocyte elastase can be slowed by inhibition of trypsin with benzamidine or by occupation of elastase's active site with elastatinal.
摘要
人白细胞弹性蛋白酶可被牛胰蛋白酶进行蛋白水解失活。猪胰弹性蛋白酶和牛胰凝乳蛋白酶均不会导致白细胞弹性蛋白酶失活，而且胰蛋白酶、胰弹性蛋白酶或凝乳蛋白酶自身也不易被蛋白水解。用苯甲脒抑制胰蛋白酶或用弹性蛋白酶抑制剂占据弹性蛋白酶的活性位点，均可减缓胰蛋白酶催化的白细胞弹性蛋白酶失活。
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