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技术说明:用于磁共振直线加速器的冷冻切片传输特性 - 时间稳定性、临床影响和变更实施。

Technical note: Cryostat transmission characterization for MR linac - temporal stability, clinical impact and change implementation.

机构信息

GenesisCare, Alexandria, NSW, Australia.

South Western Sydney Cancer Services, New South Wales Health, Liverpool, NSW, Australia.

出版信息

Med Phys. 2024 Jul;51(7):5142-5147. doi: 10.1002/mp.17021. Epub 2024 Mar 11.

Abstract

BACKGROUND

In the Unity MR linac (Elekta AB, Stockholm, Sweden), the radiation beam traverses the cryostat and the coil support structure. The resulting beam attenuation must be considered for output calibration and its variation with gantry angle must be characterized in the treatment planning system (TPS).

PURPOSE

The aim of this work was to investigate the impact of a change of the cryostat transmission characterization (CTC) curve, due to the helium level modification, on clinical treatment plan dosimetry and to report on the experience with the CTC curve update.

METHODS

Twenty stereotactic body radiotherapy (SBRT) treatment plans: 10 prostate and 10 oligo-metastatic cancer plans, prepared with a beam model incorporating the CTC curve acquired at installation time, were re-calculated using the model implementing CTC curve post helium top-up. To account for the CTC change as well as to align our system to the recent reference conditions recommendations, the new model was commissioned with the emphasis on the specifics associated with the treatment plan adaptation and the existence of the offline and online TPS components.

RESULTS

Average CTV mean dose reduction by 0.45% in prostate cases and average GTV mean dose reduction by 0.22% in oligo-metastatic cases was observed. Updated model validation showcased good agreement between measurements and TPS calculations.

CONCLUSIONS

The agreement between CTC measurements demonstrates its temporal constancy and robustness of the measurement method employed. A helium fill level change was shown to affect the CTC and led to a small but systematic dose calculation inaccuracy. Finally, model validation and end-to-end testing results presented, underscore the minimal impact of transitioning to the new beam model and new reference conditions.

摘要

背景

在 Unity MR 直线加速器(瑞典斯德哥尔摩 Elekta AB)中,辐射束贯穿于低温恒温器和线圈支撑结构。在输出校准时必须考虑由此产生的束衰减,并且必须在治疗计划系统(TPS)中描述其与机架角度的变化关系。

目的

本研究旨在探讨由于氦气水平的改变而导致低温恒温器传输特性(CTC)曲线发生变化对临床治疗计划剂量学的影响,并报告 CTC 曲线更新的经验。

方法

对 20 例立体定向体部放射治疗(SBRT)计划(10 例前列腺癌和 10 例寡转移癌计划)进行了研究。这些计划是在安装时采集的 CTC 曲线的束模型中准备的,然后使用模型重新计算了氦气加注后 CTC 曲线的剂量学。为了考虑 CTC 的变化,并使我们的系统符合最近的参考条件建议,新模型的委托重点是与治疗计划适应相关的具体问题以及离线和在线 TPS 组件的存在。

结果

在前列腺病例中,CTV 平均剂量减少了 0.45%,在寡转移病例中,GTV 平均剂量减少了 0.22%。更新后的模型验证表明,测量值与 TPS 计算值之间具有良好的一致性。

结论

CTC 测量值的一致性证明了其时间稳定性和所采用的测量方法的稳健性。氦气填充水平的变化表明 CTC 会受到影响,并导致了小但系统的剂量计算不准确。最后,呈现的模型验证和端到端测试结果强调了向新的束模型和新的参考条件过渡的最小影响。

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